{"id":8947,"date":"2021-04-12T10:34:31","date_gmt":"2021-04-12T17:34:31","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=8947"},"modified":"2021-04-13T10:35:16","modified_gmt":"2021-04-13T17:35:16","slug":"neutralization-of-sars-cov-2-variants-by-convalescent-and-vaccinated-serum","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/12\/neutralization-of-sars-cov-2-variants-by-convalescent-and-vaccinated-serum\/","title":{"rendered":"Neutralization of SARS-CoV-2 Variants by Convalescent and Vaccinated Serum"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> Sera from convalescent individuals (n = 44) and individuals who received the Pfizer-BioNTech vaccine (n = 51) showed reduced neutralization activity against the SARS-CoV-2 B.1.1.7 and B.1.351 variants. Among vaccinated individuals, the geometric mean 50% receptor binding domain (RBD) antibody concentration was 1.3-fold lower for the B.1.1.7 variant and 1.4-fold lower for the B.1.351 variant. Age was negatively correlated with neutralization among vaccinated individuals, and levels of variant-specific RBD antibodies were proportional to neutralizing activity.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Bates et al.\u00a0(Apr 9, 2021). Neutralization of SARS-CoV-2 Variants by Convalescent and Vaccinated Serum. Pre-print downloaded Apr 12 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.04.04.21254881\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.04.04.21254881<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Sera from convalescent individuals (n = 44) and individuals who received the Pfizer-BioNTech vaccine (n = 51) showed reduced neutralization activity against the SARS-CoV-2 B.1.1.7 and B.1.351 variants. Among vaccinated individuals, the geometric mean 50% receptor binding domain (RBD) antibody concentration was 1.3-fold lower for the B.1.1.7 variant and 1.4-fold lower for&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/12\/neutralization-of-sars-cov-2-variants-by-convalescent-and-vaccinated-serum\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,28,142,141],"topic":[19],"class_list":["post-8947","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-treatment","tag-vaccine","tag-variant","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=8947"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8947\/revisions"}],"predecessor-version":[{"id":8948,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/8947\/revisions\/8948"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=8947"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=8947"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=8947"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=8947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}