{"id":9058,"date":"2020-08-14T11:39:51","date_gmt":"2020-08-14T18:39:51","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9058"},"modified":"2021-04-13T11:40:29","modified_gmt":"2021-04-13T18:40:29","slug":"effect-of-an-inactivated-vaccine-against-sars-cov-2-on-safety-and-immunogenicity-outcomes","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/14\/effect-of-an-inactivated-vaccine-against-sars-cov-2-on-safety-and-immunogenicity-outcomes\/","title":{"rendered":"Effect of an Inactivated Vaccine\u00a0Against\u00a0SARS-CoV-2 on Safety and Immunogenicity Outcomes"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"52\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Xia et<\/span><span data-contrast=\"auto\">\u00a0al. report interim analyses of an ongoing randomized, double-blind, placebo-controlled phase 1 (n=96) and 2 (n=224) clinical trials of an inactivated whole-virus COVID-19 vaccine conducted in Henan Province, China. All participants who were randomized completed the trial up to 28 days\u00a0<\/span><span data-contrast=\"auto\">post-<\/span><span data-contrast=\"auto\">vaccination. Frequency of adverse reactions increased with dose<\/span><span data-contrast=\"auto\">\u00a0and the\u00a0<\/span><span data-contrast=\"auto\">most common adverse reactions were injection site pain and fever, which were mild and self-limiting, with no serious adverse reactions noted. Immunogenicity was noted in all dose groups.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:360,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Xia et al. (Aug 13, 2020). Effect of an Inactivated Vaccine\u00a0<\/span><\/i><i><span data-contrast=\"none\">Against<\/span><\/i><i><span data-contrast=\"none\">\u00a0SARS-CoV-2 on Safety and Immunogenicity Outcomes. JAMA.<\/span><\/i><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jama.2020.15543\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1001\/jama.2020.15543<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xia et\u00a0al. report interim analyses of an ongoing randomized, double-blind, placebo-controlled phase 1 (n=96) and 2 (n=224) clinical trials of an inactivated whole-virus COVID-19 vaccine conducted in Henan Province, China. All participants who were randomized completed the trial up to 28 days\u00a0post-vaccination. Frequency of adverse reactions increased with dose\u00a0and the\u00a0most common adverse reactions were injection&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/14\/effect-of-an-inactivated-vaccine-against-sars-cov-2-on-safety-and-immunogenicity-outcomes\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[31],"class_list":["post-9058","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9058"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9058\/revisions"}],"predecessor-version":[{"id":9059,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9058\/revisions\/9059"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9058"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9058"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9058"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}