{"id":9112,"date":"2021-04-13T09:48:31","date_gmt":"2021-04-13T16:48:31","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9112"},"modified":"2021-04-14T09:49:16","modified_gmt":"2021-04-14T16:49:16","slug":"rapid-decline-of-neutralizing-antibodies-is-associated-with-decay-of-igm-in-adults-recovered-from-mild-covid-19-disease","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/13\/rapid-decline-of-neutralizing-antibodies-is-associated-with-decay-of-igm-in-adults-recovered-from-mild-covid-19-disease\/","title":{"rendered":"Rapid Decline of Neutralizing Antibodies Is Associated with Decay of IgM in Adults Recovered from Mild COVID-19 Disease"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">SARS-CoV-2-specific IgG antibody levels were relatively stable for up to 6 months, whereas neutralizing antibody responses waned during that time, according to a cohort study of 34 adults with mild COVID-19. By 6 months, only 70% (23 of 33) of participants exhibited a neutralizing response compared to 91% or higher for IgG antibody responses. Presence of fever was associated with higher IgG antibody responses, while declining IgM antibody levels were strongly associated with declines in neutralizing activity.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Harrington et al.\u00a0(Mar 24, 2021). Rapid Decline of Neutralizing Antibodies Is Associated with Decay of IgM in Adults Recovered from Mild COVID-19 Disease. Cell Reports Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.xcrm.2021.100253\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.xcrm.2021.100253<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>SARS-CoV-2-specific IgG antibody levels were relatively stable for up to 6 months, whereas neutralizing antibody responses waned during that time, according to a cohort study of 34 adults with mild COVID-19. By 6 months, only 70% (23 of 33) of participants exhibited a neutralizing response compared to 91% or higher for IgG antibody responses. Presence&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/13\/rapid-decline-of-neutralizing-antibodies-is-associated-with-decay-of-igm-in-adults-recovered-from-mild-covid-19-disease\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67],"topic":[31],"class_list":["post-9112","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9112"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9112\/revisions"}],"predecessor-version":[{"id":9113,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9112\/revisions\/9113"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9112"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9112"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9112"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}