{"id":9161,"date":"2020-08-18T11:00:37","date_gmt":"2020-08-18T18:00:37","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9161"},"modified":"2021-04-15T11:01:19","modified_gmt":"2021-04-15T18:01:19","slug":"potential-antigenic-cross-reactivity-between-sars-cov-2-and-dengue-viruses","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/18\/potential-antigenic-cross-reactivity-between-sars-cov-2-and-dengue-viruses\/","title":{"rendered":"Potential Antigenic Cross-Reactivity between SARS-CoV-2 and Dengue Viruses"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">A study in Israel identified\u00a0<\/span><span data-contrast=\"auto\">potential cross-reactivity between<\/span><span data-contrast=\"auto\">\u00a0de<\/span><span data-contrast=\"auto\">ngue viruses and SARS-CoV-2\u00a0<\/span><span data-contrast=\"auto\">by testing\u00a0<\/span><span data-contrast=\"auto\">serum samples from 55 COVID-19\u00a0<\/span><span data-contrast=\"auto\">patients<\/span><span data-contrast=\"auto\">\u00a0for dengue\u00a0<\/span><span data-contrast=\"auto\">antibodies\u00a0<\/span><span data-contrast=\"auto\">and detect<\/span><span data-contrast=\"auto\">ing<\/span><span data-contrast=\"auto\">\u00a012 positive cases<\/span><span data-contrast=\"auto\">. In comparison,<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">there were no\u00a0<\/span><span data-contrast=\"auto\">positive<\/span><span data-contrast=\"auto\">s<\/span><span data-contrast=\"auto\">\u00a0for\u00a0<\/span><span data-contrast=\"auto\">dengue<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">among<\/span><span data-contrast=\"auto\">\u00a0serum samples obtained from 70 healthy individuals prior to September 2019 (p &lt; 0.001).\u00a0<\/span><span data-contrast=\"auto\">In\u00a0<\/span><span data-contrast=\"auto\">a<\/span><span data-contrast=\"auto\">\u00a0complementary analysis<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">22% (21 of\u00a0<\/span><span data-contrast=\"auto\">95<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">of\u00a0<\/span><span data-contrast=\"auto\">serum samples obtained prior to September 2019 from patients with diagnosis of past dengue fever\u00a0<\/span><span data-contrast=\"auto\">w<\/span><span data-contrast=\"auto\">ere<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">positive\u00a0<\/span><span data-contrast=\"auto\">on<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">S<\/span><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">RS-CoV-2 IgG or IgA antibod<\/span><span data-contrast=\"auto\">y tests<\/span><span data-contrast=\"auto\">\u00a0compared to\u00a0<\/span><span data-contrast=\"auto\">4% (<\/span><span data-contrast=\"auto\">4<\/span><span data-contrast=\"auto\">\u00a0of<\/span><span data-contrast=\"auto\">\u00a0102<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">of\u00a0<\/span><span data-contrast=\"auto\">healthy controls (p &lt; 0.001). The investigators suggest\u00a0<\/span><span data-contrast=\"auto\">that potential\u00a0<\/span><span data-contrast=\"auto\">cross-reactivity between dengue virus<\/span><span data-contrast=\"auto\">es<\/span><span data-contrast=\"auto\">\u00a0and SARS-CoV-2<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">could<\/span><span data-contrast=\"auto\">\u00a0lead to false positive<\/span><span data-contrast=\"auto\">\u00a0tests<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Lustig et al. (Aug 14, 2020). Potential Antigenic Cross-Reactivity between SARS-CoV-2 and Dengue Viruses. Clinical Infectious Diseases.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa1207\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1093\/cid\/ciaa1207<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559685&quot;:720,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study in Israel identified\u00a0potential cross-reactivity between\u00a0dengue viruses and SARS-CoV-2\u00a0by testing\u00a0serum samples from 55 COVID-19\u00a0patients\u00a0for dengue\u00a0antibodies\u00a0and detecting\u00a012 positive cases. In comparison,\u00a0there were no\u00a0positives\u00a0for\u00a0dengue\u00a0among\u00a0serum samples obtained from 70 healthy individuals prior to September 2019 (p &lt; 0.001).\u00a0In\u00a0a\u00a0complementary analysis,\u00a022% (21 of\u00a095)\u00a0of\u00a0serum samples obtained prior to September 2019 from patients with diagnosis of past dengue fever\u00a0were\u00a0positive\u00a0on\u00a0SARS-CoV-2 IgG or&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/18\/potential-antigenic-cross-reactivity-between-sars-cov-2-and-dengue-viruses\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-9161","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9161"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9161\/revisions"}],"predecessor-version":[{"id":9162,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9161\/revisions\/9162"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9161"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}