{"id":9186,"date":"2020-08-19T11:14:49","date_gmt":"2020-08-19T18:14:49","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9186"},"modified":"2021-04-15T11:25:05","modified_gmt":"2021-04-15T18:25:05","slug":"ofosbuvir-and-daclatasvir-compared-with-standard-of-care-in-the-treatment-of-patients-admitted-to-hospital-with-moderate-or-severe-coronavirus-infection-covid-19-a-randomized-controlled-trial","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/19\/ofosbuvir-and-daclatasvir-compared-with-standard-of-care-in-the-treatment-of-patients-admitted-to-hospital-with-moderate-or-severe-coronavirus-infection-covid-19-a-randomized-controlled-trial\/","title":{"rendered":"Sofosbuvir and Daclatasvir Compared with Standard of Care in the Treatment of Patients Admitted to Hospital with Moderate or Severe Coronavirus Infection (COVID-19): A Randomized Controlled Trial"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">In an open-label, multicente<\/span><span data-contrast=\"auto\">r<\/span><span data-contrast=\"auto\">, randomized clinical trial in adults with moderate or severe COVID-19 admitted to\u00a0<\/span><span data-contrast=\"auto\">four<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">university hospitals in Iran<\/span><span data-contrast=\"auto\">, the addition of\u00a0<\/span><span data-contrast=\"auto\">drugs used to treat hepatitis C<\/span><span data-contrast=\"auto\">\u00a0viru<\/span><span data-contrast=\"auto\">s,\u00a0<\/span><span data-contrast=\"auto\">sofosbuvir and daclatasvir<\/span><span data-contrast=\"auto\">,<\/span><span data-contrast=\"auto\">\u00a0to standard care\u00a0<\/span><span data-contrast=\"auto\">(n=33)\u00a0<\/span><span data-contrast=\"auto\">significantly reduced the duration of hospital stay compared with standard care alone<\/span><span data-contrast=\"auto\">\u00a0(n=33)<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Cumulative incidence of hospital discharge was significantly higher in the treatment<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">versus the control<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">arm<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Although fewer deaths were observed in the treatment arm,\u00a0<\/span><span data-contrast=\"auto\">the difference was\u00a0<\/span><span data-contrast=\"auto\">not statistically significant.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Sadeghi et al. (Aug 19, 2020). Sofosbuvir and Daclatasvir Compared with Standard of Care in the Treatment of Patients Admitted to Hospital with Moderate or Severe Coronavirus Infection (COVID-19): A Randomized Controlled Trial. Journal of Antimicrobial Chemotherapy.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/jac\/dkaa334\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1093\/jac\/dkaa334<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;335559685&quot;:720}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In an open-label, multicenter, randomized clinical trial in adults with moderate or severe COVID-19 admitted to\u00a0four\u00a0university hospitals in Iran, the addition of\u00a0drugs used to treat hepatitis C\u00a0virus,\u00a0sofosbuvir and daclatasvir,\u00a0to standard care\u00a0(n=33)\u00a0significantly reduced the duration of hospital stay compared with standard care alone\u00a0(n=33).\u00a0Cumulative incidence of hospital discharge was significantly higher in the treatment\u00a0versus the control\u00a0arm.\u00a0Although fewer&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/19\/ofosbuvir-and-daclatasvir-compared-with-standard-of-care-in-the-treatment-of-patients-admitted-to-hospital-with-moderate-or-severe-coronavirus-infection-covid-19-a-randomized-controlled-trial\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[19],"class_list":["post-9186","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9186"}],"version-history":[{"count":2,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9186\/revisions"}],"predecessor-version":[{"id":9207,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9186\/revisions\/9207"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9186"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}