{"id":9188,"date":"2020-08-19T11:15:40","date_gmt":"2020-08-19T18:15:40","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9188"},"modified":"2021-04-15T11:16:23","modified_gmt":"2021-04-15T18:16:23","slug":"neutralizing-antibodies-correlate-with-protection-from-sars-cov-2-in-humans-during-a-fishery-vessel-outbreak-with-high-attack-rate","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/19\/neutralizing-antibodies-correlate-with-protection-from-sars-cov-2-in-humans-during-a-fishery-vessel-outbreak-with-high-attack-rate\/","title":{"rendered":"Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with High Attack Rate"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><i><span data-contrast=\"none\">[Pre-print, not peer reviewed]<\/span><\/i><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><span data-contrast=\"auto\">Three individuals with pre-existing neutralizing antibodies against SARS-CoV-2 were not re-infected while they were aboard a\u00a0<\/span><span data-contrast=\"auto\">fishing vessel\u00a0<\/span><span data-contrast=\"auto\">that experienced a SARS-CoV-2 outbreak with\u00a0<\/span><span data-contrast=\"auto\">a high attack rate<\/span><span data-contrast=\"auto\">, providing some of the first direct evidence for potential immunity following infection<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Out of a crew of 122, a<\/span><span data-contrast=\"auto\">\u00a0total of 104 individuals had a<\/span><span data-contrast=\"auto\">\u00a0positive SARS-CoV-2\u00a0<\/span><span data-contrast=\"auto\">RT-PCR test\u00a0<\/span><span data-contrast=\"auto\">or\u00a0<\/span><span data-contrast=\"auto\">seroconverted during the follow-up period (attack rate<\/span><span data-contrast=\"auto\">\u00a0of\u00a0<\/span><span data-contrast=\"auto\">85%).<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Only three crewmembers tested seropositive prior to the boat&#8217;s departure in initial serological screening\u00a0<\/span><span data-contrast=\"auto\">and also<\/span><span data-contrast=\"auto\">\u00a0had neutralizing and spike-reactive antibodies in follow-up assays. None of these crewmembers with neutralizing antibody titers showed evidence of bona fide viral infection or experienced any symptoms during the viral outbreak.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Addetia<\/span><\/i><i><span data-contrast=\"none\">\u00a0et al. (Aug 14, 2020). Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with High Attack Rate. Pre-print downloaded Aug 19 from\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2020.08.13.20173161\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1101\/2020.08.13.20173161<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;335559685&quot;:720}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer reviewed]\u00a0Three individuals with pre-existing neutralizing antibodies against SARS-CoV-2 were not re-infected while they were aboard a\u00a0fishing vessel\u00a0that experienced a SARS-CoV-2 outbreak with\u00a0a high attack rate, providing some of the first direct evidence for potential immunity following infection.\u00a0Out of a crew of 122, a\u00a0total of 104 individuals had a\u00a0positive SARS-CoV-2\u00a0RT-PCR test\u00a0or\u00a0seroconverted during the&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/19\/neutralizing-antibodies-correlate-with-protection-from-sars-cov-2-in-humans-during-a-fishery-vessel-outbreak-with-high-attack-rate\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[31],"class_list":["post-9188","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9188","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9188"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9188\/revisions"}],"predecessor-version":[{"id":9189,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9188\/revisions\/9189"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9188"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9188"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9188"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9188"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}