{"id":9196,"date":"2020-08-19T11:19:08","date_gmt":"2020-08-19T18:19:08","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9196"},"modified":"2021-04-15T11:19:50","modified_gmt":"2021-04-15T18:19:50","slug":"effects-of-a-major-deletion-in-the-sars-cov-2-genome-on-the-severity-of-infection-and-the-inflammatory-response-an-observational-cohort-study","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/19\/effects-of-a-major-deletion-in-the-sars-cov-2-genome-on-the-severity-of-infection-and-the-inflammatory-response-an-observational-cohort-study\/","title":{"rendered":"Effects of a Major Deletion in the SARS-CoV-2 Genome on the Severity of Infection and the Inflammatory Response: An Observational Cohort Study"},"content":{"rendered":"<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"34\" data-aria-posinset=\"2019\" data-aria-level=\"1\"><span data-contrast=\"auto\">Findings from a<\/span><span data-contrast=\"auto\">\u00a0prospective observational cohort study conducted at\u00a0<\/span><span data-contrast=\"auto\">seven<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">public hospitals in Singapore<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">show that\u00a0<\/span><span data-contrast=\"auto\">the<\/span><span data-contrast=\"auto\">\u00a0382-nucleotide deletion (\u2206382)\u00a0<\/span><span data-contrast=\"auto\">variant of\u00a0<\/span><span data-contrast=\"auto\">SARS-CoV-2\u00a0<\/span><span data-contrast=\"auto\">is\u00a0<\/span><span data-contrast=\"auto\">associated with a milder infection<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0Individuals infected with the \u2206382 variant were compared with those infected with wild-type SARS-CoV-2.<\/span><span data-contrast=\"auto\">\u00a0Between Jan<\/span><span data-contrast=\"auto\">uary<\/span><span data-contrast=\"auto\">\u00a022 and March 21,\u00a0<\/span><span data-contrast=\"auto\">among\u00a0<\/span><span data-contrast=\"auto\">131\u00a0<\/span><span data-contrast=\"auto\">individuals<\/span><span data-contrast=\"auto\">\u00a0enrolled, 70% were infected with the wild-type virus, 8% had a mix of wild-type and \u2206382-variant viruses, and 22%<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">had only the \u2206382 variant.\u00a0<\/span><span data-contrast=\"auto\">After adjusting for age and presence of comorbidities, infection with the \u2206382 variant only was associated with\u00a0<\/span><span data-contrast=\"auto\">a 93% lower\u00a0<\/span><span data-contrast=\"auto\">odds\u00a0of developing hypoxia<\/span><span data-contrast=\"auto\">\u00a0requiring supplemental oxygen<\/span><span data-contrast=\"auto\">,\u00a0<\/span><span data-contrast=\"auto\">compared with infection with wild-type virus only.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span data-contrast=\"none\">Young et al. (Aug\u00a0<\/span><\/i><i><span data-contrast=\"none\">18,\u00a0<\/span><\/i><i><span data-contrast=\"none\">2020). Effects of a Major Deletion in the SARS-CoV-2 Genome on the Severity of Infection and the Inflammatory Response: An Observational Cohort Study. The Lancet.\u00a0<\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(20)31757-8\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1016\/S0140-6736(20)31757-8<\/span><\/a><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;335559685&quot;:720}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Findings from a\u00a0prospective observational cohort study conducted at\u00a0seven\u00a0public hospitals in Singapore\u00a0show that\u00a0the\u00a0382-nucleotide deletion (\u2206382)\u00a0variant of\u00a0SARS-CoV-2\u00a0is\u00a0associated with a milder infection.\u00a0Individuals infected with the \u2206382 variant were compared with those infected with wild-type SARS-CoV-2.\u00a0Between January\u00a022 and March 21,\u00a0among\u00a0131\u00a0individuals\u00a0enrolled, 70% were infected with the wild-type virus, 8% had a mix of wild-type and \u2206382-variant viruses, and 22%\u00a0had only&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2020\/08\/19\/effects-of-a-major-deletion-in-the-sars-cov-2-genome-on-the-severity-of-infection-and-the-inflammatory-response-an-observational-cohort-study\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[],"topic":[20],"class_list":["post-9196","post","type-post","status-publish","format-standard","hentry","category-article-summary","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9196"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9196\/revisions"}],"predecessor-version":[{"id":9197,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9196\/revisions\/9197"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9196"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}