{"id":9227,"date":"2021-04-15T13:59:38","date_gmt":"2021-04-15T20:59:38","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9227"},"modified":"2021-04-16T14:00:30","modified_gmt":"2021-04-16T21:00:30","slug":"vaccination-boosts-protective-responses-and-counters-sars-cov-2-induced-pathogenic-memory-b-cells","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/15\/vaccination-boosts-protective-responses-and-counters-sars-cov-2-induced-pathogenic-memory-b-cells\/","title":{"rendered":"Vaccination Boosts Protective Responses and Counters SARS-CoV-2-Induced Pathogenic Memory B Cells"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> SARS-CoV-2 specific B cells isolated from individuals who had recovered from SARS-CoV-2 infection appeared similar to B cells isolated previously described in individuals with chronic infections or inflammation (IgD negative, CD27 negative), according to a longitudinal study of convalescent individuals (n=22). After vaccination, the frequency of IgD\/CD27 negative cells (\u201cdouble negative\u201d) decreased. A more robust immune response elicited by vaccination among individuals with prior infection compared to na\u00efve individuals was documented by comparing memory B cell responses of this cohort with those of non-infected vaccinated controls.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Mishra et al.\u00a0(Apr 14, 2021). Vaccination Boosts Protective Responses and Counters SARS-CoV-2-Induced Pathogenic Memory B Cells. Pre-print downloaded Apr 15 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.04.11.21255153\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.04.11.21255153<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] SARS-CoV-2 specific B cells isolated from individuals who had recovered from SARS-CoV-2 infection appeared similar to B cells isolated previously described in individuals with chronic infections or inflammation (IgD negative, CD27 negative), according to a longitudinal study of convalescent individuals (n=22). After vaccination, the frequency of IgD\/CD27 negative cells (\u201cdouble negative\u201d) decreased&#8230;.<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/15\/vaccination-boosts-protective-responses-and-counters-sars-cov-2-induced-pathogenic-memory-b-cells\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,51,147],"topic":[31],"class_list":["post-9227","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-sequelae","tag-vaccination","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9227"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9227\/revisions"}],"predecessor-version":[{"id":9228,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9227\/revisions\/9228"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9227"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9227"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9227"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}