{"id":9246,"date":"2021-04-16T11:52:29","date_gmt":"2021-04-16T18:52:29","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9246"},"modified":"2021-04-19T11:53:14","modified_gmt":"2021-04-19T18:53:14","slug":"distinct-antibody-and-memory-b-cell-responses-in-sars-cov-2-naive-and-recovered-individuals-following-mrna-vaccination","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/16\/distinct-antibody-and-memory-b-cell-responses-in-sars-cov-2-naive-and-recovered-individuals-following-mrna-vaccination\/","title":{"rendered":"Distinct Antibody and Memory B Cell Responses in SARS-CoV-2 Na\u00efve and Recovered Individuals Following mRNA Vaccination"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A single dose of an mRNA vaccine (Moderna or Pfizer-BioNTech) administered to SARS-CoV-2 na\u00efve individuals produced neutralizing activity against the D614G variant in 50% of recipients and against the B.1.351 variant in 16% of recipients (n=33). Neutralizing activity improved to 100% against the D614G variant and 96% against the against the B.1.351 variant following a second dose. Two doses of the vaccine were also required to achieve levels of SARS-CoV-2 RBD-specific memory B cells that were comparable to what is seen in non-vaccinated individuals who have recovered from COVID-19.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">By contrast, neutralizing antibody activity and antigen-specific memory B cell levels in individuals who had recovered from a SARS-CoV-2 infection were significantly boosted after the first vaccine dose and did not significantly change after the second dose.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Goel et al.\u00a0(Apr 15, 2021). Distinct Antibody and Memory B Cell Responses in SARS-CoV-2 Na\u00efve and Recovered Individuals Following mRNA Vaccination. Science Immunology. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1126\/sciimmunol.abi6950\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1126\/sciimmunol.abi6950<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A single dose of an mRNA vaccine (Moderna or Pfizer-BioNTech) administered to SARS-CoV-2 na\u00efve individuals produced neutralizing activity against the D614G variant in 50% of recipients and against the B.1.351 variant in 16% of recipients (n=33). Neutralizing activity improved to 100% against the D614G variant and 96% against the against the B.1.351 variant following a&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/16\/distinct-antibody-and-memory-b-cell-responses-in-sars-cov-2-naive-and-recovered-individuals-following-mrna-vaccination\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[201,142],"topic":[31],"class_list":["post-9246","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immune-response","tag-vaccine","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9246"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9246\/revisions"}],"predecessor-version":[{"id":9247,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9246\/revisions\/9247"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9246"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9246"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9246"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}