{"id":9276,"date":"2021-04-19T09:57:46","date_gmt":"2021-04-19T16:57:46","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9276"},"modified":"2021-04-20T09:58:20","modified_gmt":"2021-04-20T16:58:20","slug":"randomized-comparative-clinical-trial-to-evaluate-efficacy-and-safety-of-pnb001-in-moderate-covid-19-patients","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/19\/randomized-comparative-clinical-trial-to-evaluate-efficacy-and-safety-of-pnb001-in-moderate-covid-19-patients\/","title":{"rendered":"Randomized Comparative Clinical Trial to Evaluate Efficacy and Safety of PNB001 in Moderate COVID-19 Patients"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> Patients with moderate COVID-19 (n=40) randomized to treatment with the novel anti-inflammatory medication <\/span><span style=\"font-weight: 400\">PNB001 <\/span><span style=\"font-weight: 400\">had <\/span><span style=\"font-weight: 400\">lower clinical severity scores assessed by the <\/span><span style=\"font-weight: 400\">8-point <\/span><span style=\"font-weight: 400\">WHO Ordinal <\/span><span style=\"font-weight: 400\">S<\/span><span style=\"font-weight: 400\">cale <\/span><span style=\"font-weight: 400\">for COVID-19 <\/span><span style=\"font-weight: 400\">at day 14 than patients who received standard of care alone (score 0.2 vs. 1.1, p&lt;0.05). The multicenter randomized trial did not detect a difference in the other primary endpoint of mortality, with 1 death in the PNB001 group and 2 deaths in the standard of care group. Three severe adverse events occurred, though none were found to be related to the study medication.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Lattman et al.\u00a0(Apr 16, 2021). Randomized Comparative Clinical Trial to Evaluate Efficacy and Safety of PNB001 in Moderate COVID-19 Patients. Pre-print downloaded Apr 19 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.04.16.21255256\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.04.16.21255256<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Patients with moderate COVID-19 (n=40) randomized to treatment with the novel anti-inflammatory medication PNB001 had lower clinical severity scores assessed by the 8-point WHO Ordinal Scale for COVID-19 at day 14 than patients who received standard of care alone (score 0.2 vs. 1.1, p&lt;0.05). The multicenter randomized trial did not detect a&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/19\/randomized-comparative-clinical-trial-to-evaluate-efficacy-and-safety-of-pnb001-in-moderate-covid-19-patients\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-9276","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9276"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9276\/revisions"}],"predecessor-version":[{"id":9277,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9276\/revisions\/9277"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9276"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}