{"id":9278,"date":"2021-04-19T09:58:27","date_gmt":"2021-04-19T16:58:27","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9278"},"modified":"2021-04-20T09:59:04","modified_gmt":"2021-04-20T16:59:04","slug":"impact-of-convalescent-plasma-therapy-on-sars-cov-2-antibody-profile-in-covid-19-patients","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/19\/impact-of-convalescent-plasma-therapy-on-sars-cov-2-antibody-profile-in-covid-19-patients\/","title":{"rendered":"Impact of Convalescent Plasma Therapy on SARS CoV-2 Antibody Profile in COVID-19 Patients"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Convalescent plasma (CP) treatment did not predict survival in a longitudinal analysis of plasma samples from hospitalized patients with COVID-19 (n = 16) treated with either CP or standard of care. Among 8 patients who died, marked declines in neutralization titers were observed prior to death, which CP treatment did not reverse. Irrespective of CP treatment, higher antibody affinity to the SARS-CoV-2 prefusion spike was associated with survival, while sustained elevated IgA response was associated with mortality. The authors suggest that more severely-ill patients may be less likely to benefit from CP treatment.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Tang et al.\u00a0(Apr 2021). Impact of Convalescent Plasma Therapy on SARS CoV-2 Antibody Profile in COVID-19 Patients. Clinical Infectious Diseases. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciab317\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1093\/cid\/ciab317<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Convalescent plasma (CP) treatment did not predict survival in a longitudinal analysis of plasma samples from hospitalized patients with COVID-19 (n = 16) treated with either CP or standard of care. Among 8 patients who died, marked declines in neutralization titers were observed prior to death, which CP treatment did not reverse. Irrespective of CP&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/19\/impact-of-convalescent-plasma-therapy-on-sars-cov-2-antibody-profile-in-covid-19-patients\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-9278","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9278"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9278\/revisions"}],"predecessor-version":[{"id":9279,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9278\/revisions\/9279"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9278"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9278"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9278"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}