{"id":9280,"date":"2021-04-19T09:59:10","date_gmt":"2021-04-19T16:59:10","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9280"},"modified":"2021-04-20T09:59:46","modified_gmt":"2021-04-20T16:59:46","slug":"reduced-humoral-response-to-mrna-sars%e2%80%90cov%e2%80%902-bnt162b2-vaccine-in-kidney-transplant-recipients-without-prior-exposure-to-the-virus","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/19\/reduced-humoral-response-to-mrna-sars%e2%80%90cov%e2%80%902-bnt162b2-vaccine-in-kidney-transplant-recipients-without-prior-exposure-to-the-virus\/","title":{"rendered":"Reduced Humoral Response to MRNA SARS\u2010Cov\u20102 BNT162b2 Vaccine in Kidney Transplant Recipients without Prior Exposure to the Virus"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Few kidney transplant recipients (51\/136, 38.5%) who had been fully vaccinated with the Pfizer-BioNTech vaccine developed a positive response to the SARS-CoV-2 spike protein, suggesting that this population may remain at risk of infection despite vaccination. Compared to controls, mean IgG anti<\/span><span style=\"font-weight: 400\">\u2010<\/span><span style=\"font-weight: 400\">spike levels were lower (31.05 vs 200.5 AU\/mL). Older age (OR = 1.7), use of <\/span><span style=\"font-weight: 400\">high dose corticosteroids in the last 12 months (OR = 1.3), and a treatment regimen that included mycophenolate (OR = 1.5) were associated with negative serology.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Grupper et al.\u00a0(Apr 18, 2021). Reduced Humoral Response to MRNA SARS\u2010Cov\u20102 BNT162b2 Vaccine in Kidney Transplant Recipients without Prior Exposure to the Virus. American Journal of Transplantation. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1111\/ajt.16615\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1111\/ajt.16615<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Few kidney transplant recipients (51\/136, 38.5%) who had been fully vaccinated with the Pfizer-BioNTech vaccine developed a positive response to the SARS-CoV-2 spike protein, suggesting that this population may remain at risk of infection despite vaccination. Compared to controls, mean IgG anti\u2010spike levels were lower (31.05 vs 200.5 AU\/mL). Older age (OR = 1.7), use&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/19\/reduced-humoral-response-to-mrna-sars%e2%80%90cov%e2%80%902-bnt162b2-vaccine-in-kidney-transplant-recipients-without-prior-exposure-to-the-virus\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[142],"topic":[31],"class_list":["post-9280","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9280"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9280\/revisions"}],"predecessor-version":[{"id":9281,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9280\/revisions\/9281"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9280"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}