{"id":9288,"date":"2021-04-19T10:02:31","date_gmt":"2021-04-19T17:02:31","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9288"},"modified":"2021-04-20T10:03:53","modified_gmt":"2021-04-20T17:03:53","slug":"humoral-and-cellular-immune-responses-against-sars-cov-2-variants-and-human-coronaviruses-after-single-bnt162b2-vaccination","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/19\/humoral-and-cellular-immune-responses-against-sars-cov-2-variants-and-human-coronaviruses-after-single-bnt162b2-vaccination\/","title":{"rendered":"Humoral and Cellular Immune Responses against SARS-CoV-2 Variants and Human Coronaviruses after Single BNT162b2 Vaccination"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> An assessment of humoral and T cell responses against a wild type SARS-CoV-2 strain, variants of concern (B.1.1.7, B.1.351, and P.1), and endemic human coronaviruses (hCov) induced after the Pfizer-BioNTech vaccine found that IgG against the <\/span><span style=\"font-weight: 400\">receptor-binding domain of the SARS-CoV-2 S protein<\/span><span style=\"font-weight: 400\"> was readily detectable at day 14, but <\/span><span style=\"font-weight: 400\">inhibition of SARS-CoV-2 S-driven host cell entry was weak and particularly low for the B.1.351 variant. After one vaccine dose, frequencies of SARS-CoV-2 specific T cells were low in many vaccine recipients and influenced by immunity against endemic hCoV. The second vaccination significantly boosted T cell frequencies reactive for the wild type SARS-CoV-2 strain, as well as B.1.1.7 and B.1.351 variants.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Stankov et al.\u00a0(Apr 16, 2021). Humoral and Cellular Immune Responses against SARS-CoV-2 Variants and Human Coronaviruses after Single BNT162b2 Vaccination. Pre-print downloaded Apr 19 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.04.16.21255412\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.04.16.21255412<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] An assessment of humoral and T cell responses against a wild type SARS-CoV-2 strain, variants of concern (B.1.1.7, B.1.351, and P.1), and endemic human coronaviruses (hCov) induced after the Pfizer-BioNTech vaccine found that IgG against the receptor-binding domain of the SARS-CoV-2 S protein was readily detectable at day 14, but inhibition of&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/19\/humoral-and-cellular-immune-responses-against-sars-cov-2-variants-and-human-coronaviruses-after-single-bnt162b2-vaccination\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,147,159],"topic":[31],"class_list":["post-9288","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-vaccination","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9288"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9288\/revisions"}],"predecessor-version":[{"id":9289,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9288\/revisions\/9289"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9288"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}