{"id":9304,"date":"2021-04-20T13:09:19","date_gmt":"2021-04-20T20:09:19","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9304"},"modified":"2021-04-22T13:09:59","modified_gmt":"2021-04-22T20:09:59","slug":"identification-of-natural-sars-cov-2-infection-in-seroprevalence-studies-among-vaccinated-populations","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/20\/identification-of-natural-sars-cov-2-infection-in-seroprevalence-studies-among-vaccinated-populations\/","title":{"rendered":"Identification of Natural SARS-CoV-2 Infection in Seroprevalence Studies among Vaccinated Populations"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> Anti-nucleocapsid protein (N) antibodies were found to be an accurate method for differentiating between antibodies produced by natural infection and antibodies produced in response to vaccination, according to a study of healthcare workers (n=82). Participants were tested for anti-spike (S) IgG antibodies and anti-N IgG at two time points. No participants were vaccinated prior to the first time point and 46% reported vaccination by the second time point. Anti-spike antibodies were detectable prior to vaccination in 9.5% of participants. Among those with no prior infection at the second assay, anti-N levels were not significantly different by vaccination status whereas anti-S1 and S2 levels were elevated among vaccinated individuals. In contrast, anti-S1, S2, and N IgG levels were significantly elevated among infected vs uninfected individuals regardless of vaccination status. [<\/span><i><span style=\"font-weight: 400\">EDITORIAL NOTE: Details on which vaccine participants received was not included but presumably were one of the EUA-approved vaccines in the US, all of which do not include a nucleocapsid insert. These data may not apply to all vaccines.<\/span><\/i><span style=\"font-weight: 400\">]<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Demmer et al.\u00a0(Apr 19, 2021). Identification of Natural SARS-CoV-2 Infection in Seroprevalence Studies among Vaccinated Populations. Pre-print downloaded Apr 20 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.04.12.21255330\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.04.12.21255330<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Anti-nucleocapsid protein (N) antibodies were found to be an accurate method for differentiating between antibodies produced by natural infection and antibodies produced in response to vaccination, according to a study of healthcare workers (n=82). Participants were tested for anti-spike (S) IgG antibodies and anti-N IgG at two time points. No participants were&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/20\/identification-of-natural-sars-cov-2-infection-in-seroprevalence-studies-among-vaccinated-populations\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,33],"topic":[31],"class_list":["post-9304","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9304","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9304"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9304\/revisions"}],"predecessor-version":[{"id":9305,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9304\/revisions\/9305"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9304"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9304"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9304"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9304"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}