{"id":9353,"date":"2021-04-22T15:38:12","date_gmt":"2021-04-22T22:38:12","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9353"},"modified":"2021-04-23T15:38:46","modified_gmt":"2021-04-23T22:38:46","slug":"comparative-analysis-of-emerging-b-1-1-7e484k-sars-cov-2-isolates-from-pennsylvania","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/22\/comparative-analysis-of-emerging-b-1-1-7e484k-sars-cov-2-isolates-from-pennsylvania\/","title":{"rendered":"Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates from Pennsylvania"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> A SARS-CoV-2 B.1.1.7 sequence from Pennsylvania detected in March 2021 was found to have the E484K spike substitution, a mutation shown to confer resistance to neutralizing antibodies. Only 60 isolates with the B.1.1.7+E484K sequence profile have been detected in the US, and only 253 reported globally. Comparative genomic <\/span><i><span style=\"font-weight: 400\">analysis<\/span><\/i><span style=\"font-weight: 400\"> of 235 high coverage genomes suggests at least 7 independent acquisitions of the E484K substitution by the B.1.1.7 lineage.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Ahmed et al.\u00a0(Apr 21, 2021). Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates from Pennsylvania. Pre-print downloaded Apr 22 from <\/span><\/i><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.04.21.440801v1.full.pdf\"><span style=\"font-weight: 400\">https:\/\/www.biorxiv.org\/content\/10.1101\/2021.04.21.440801v1.full.pdf<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A SARS-CoV-2 B.1.1.7 sequence from Pennsylvania detected in March 2021 was found to have the E484K spike substitution, a mutation shown to confer resistance to neutralizing antibodies. Only 60 isolates with the B.1.1.7+E484K sequence profile have been detected in the US, and only 253 reported globally. Comparative genomic analysis of 235 high&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/22\/comparative-analysis-of-emerging-b-1-1-7e484k-sars-cov-2-isolates-from-pennsylvania\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[159],"topic":[24],"class_list":["post-9353","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-variants","topic-geographic-spread"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9353"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9353\/revisions"}],"predecessor-version":[{"id":9354,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9353\/revisions\/9354"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9353"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}