{"id":9361,"date":"2021-04-22T15:41:16","date_gmt":"2021-04-22T22:41:16","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9361"},"modified":"2021-04-23T15:42:02","modified_gmt":"2021-04-23T22:42:02","slug":"vaccine-breakthrough-infections-with-sars-cov-2-variants","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/22\/vaccine-breakthrough-infections-with-sars-cov-2-variants\/","title":{"rendered":"Vaccine Breakthrough Infections with SARS-CoV-2 Variants"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">2 SARS-CoV-2 breakthrough infections (infection &gt;= 14 days after the second vaccine dose) were detected in a cohort of 417 employees at the Rockefeller University in New York City. Clinical symptoms of COVID-19 developed 19 days after Patient 1 (51-year-old woman) received their second dose of the Moderna vaccine, and 36 days after Patient 2 (65-year old woman) received their second dose of the Pfizer-BioNTech vaccine. Both patients were healthy and had typical clinical responses to the second dose. Viral genome sequences from both patients show that neither was infected with wild-type SARS-CoV-2. Specifically, the sequence from Patient 1 contained spike mutations including E484K, which is known to confer resistance to neutralizing antibodies. The sequences did not precisely fit any known clade.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Hacisuleyman et al.\u00a0(Apr 21, 2021). Vaccine Breakthrough Infections with SARS-CoV-2 Variants. New England Journal of Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2105000\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1056\/NEJMoa2105000<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2 SARS-CoV-2 breakthrough infections (infection &gt;= 14 days after the second vaccine dose) were detected in a cohort of 417 employees at the Rockefeller University in New York City. Clinical symptoms of COVID-19 developed 19 days after Patient 1 (51-year-old woman) received their second dose of the Moderna vaccine, and 36 days after Patient 2&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/22\/vaccine-breakthrough-infections-with-sars-cov-2-variants\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_members_access_role":[],"_members_access_error":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[222,159],"topic":[31],"class_list":["post-9361","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine-breakthrough","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9361"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9361\/revisions"}],"predecessor-version":[{"id":9362,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9361\/revisions\/9362"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9361"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}