{"id":9446,"date":"2021-04-27T10:18:41","date_gmt":"2021-04-27T17:18:41","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9446"},"modified":"2021-04-28T10:19:28","modified_gmt":"2021-04-28T17:19:28","slug":"genomic-epidemiology-of-sars-cov-2-infection-during-the-initial-pandemic-wave-and-association-with-disease-severity","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/27\/genomic-epidemiology-of-sars-cov-2-infection-during-the-initial-pandemic-wave-and-association-with-disease-severity\/","title":{"rendered":"Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The SARS-CoV-2 D614G variant was associated with increased survival in hospitalized patients (86% vs 59% for other identified variants) according to analysis from a repeated cross-sectional study (n=302) of SARS-CoV-2 isolates from the Cleveland Clinic during the first wave of infection (March to April 2020). While 6 different clades were initially identified in the beginning of the study, clade diversity rapidly decreased with D614G isolates comprising 64% of samples (21 of 33) in week 1 to 93% of samples (28 of 30) by week 6. The authors suggest these findings may help explain decreasing mortality among those hospitalized throughout the pandemic.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Esper et al.\u00a0(Apr 26, 2021). Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity. JAMA Network Open. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.7746\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.7746<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The SARS-CoV-2 D614G variant was associated with increased survival in hospitalized patients (86% vs 59% for other identified variants) according to analysis from a repeated cross-sectional study (n=302) of SARS-CoV-2 isolates from the Cleveland Clinic during the first wave of infection (March to April 2020). While 6 different clades were initially identified in the beginning&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/27\/genomic-epidemiology-of-sars-cov-2-infection-during-the-initial-pandemic-wave-and-association-with-disease-severity\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34,159],"topic":[20],"class_list":["post-9446","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","tag-variants","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9446","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9446"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9446\/revisions"}],"predecessor-version":[{"id":9447,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9446\/revisions\/9447"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9446"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9446"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9446"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9446"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}