{"id":9461,"date":"2021-04-28T13:25:25","date_gmt":"2021-04-28T20:25:25","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9461"},"modified":"2021-04-29T13:26:02","modified_gmt":"2021-04-29T20:26:02","slug":"a-randomised-clinical-trial-of-azithromycin-versus-standard-care-in-ambulatory-covid-19-the-atomic2-trial","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/28\/a-randomised-clinical-trial-of-azithromycin-versus-standard-care-in-ambulatory-covid-19-the-atomic2-trial\/","title":{"rendered":"A Randomised Clinical Trial of Azithromycin versus Standard Care in Ambulatory COVID-19 &#8211; the ATOMIC2 Trial"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> In a 1:1 randomized open-label trial among ambulatory patients with mild-moderate COVID-19 in the UK (n=292), those randomized to receive the antibiotic azithromycin had no significance difference in death or hospitalization within 28 days compared to patients receiving standard care (OR=0.91, 95% CI: 0.43-1.92). Rates of respiratory failure, progression to pneumonia, all-cause mortality, and adverse events, including serious cardiovascular events, were not significantly different between groups.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Hinks et al.\u00a0(Apr 27, 2021). A Randomised Clinical Trial of Azithromycin versus Standard Care in Ambulatory COVID-19 &#8211; the ATOMIC2 Trial. Pre-print downloaded Apr 28 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.04.21.21255807\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.04.21.21255807<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] In a 1:1 randomized open-label trial among ambulatory patients with mild-moderate COVID-19 in the UK (n=292), those randomized to receive the antibiotic azithromycin had no significance difference in death or hospitalization within 28 days compared to patients receiving standard care (OR=0.91, 95% CI: 0.43-1.92). Rates of respiratory failure, progression to pneumonia, all-cause&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/28\/a-randomised-clinical-trial-of-azithromycin-versus-standard-care-in-ambulatory-covid-19-the-atomic2-trial\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-9461","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9461"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9461\/revisions"}],"predecessor-version":[{"id":9462,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9461\/revisions\/9462"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9461"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}