{"id":9463,"date":"2021-04-28T13:26:11","date_gmt":"2021-04-28T20:26:11","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9463"},"modified":"2021-04-29T13:26:49","modified_gmt":"2021-04-29T20:26:49","slug":"longitudinal-analysis-shows-durable-and-broad-immune-memory-after-sars-cov-2-infection-with-persisting-antibody-responses-and-memory-b-and-t-cells","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/28\/longitudinal-analysis-shows-durable-and-broad-immune-memory-after-sars-cov-2-infection-with-persisting-antibody-responses-and-memory-b-and-t-cells\/","title":{"rendered":"Longitudinal Analysis Shows Durable and Broad Immune Memory after SARS-CoV-2 Infection with Persisting Antibody Responses and Memory B and T Cells"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> Longitudinal assessment of immune memory response found that SARS-CoV-2 antibodies exhibited an initial rapid decline from peak levels followed by a much slower decrease (\u201cplateau-phase\u201d). Among 254 recovered COVID-19 patients up to 8 months after symptom onset, anti-spike IgG antibodies were estimated to have an initial half-life of 126 days up to 120 days after symptom onset, then a half-life of 238 days after 120 days from symptom onset. The authors suggest that this pattern is consistent with the generation of longer-lived antibody producing plasma cells. A similar biphasic pattern was observed with neutralizing antibodies, as the estimated half-life before and after 120 days from symptom onset was 150 days and 254 days, respectively. Of the 67 patients with data between 180-263 days after symptom onset, 48 (72%) continued to generate neutralizing antibodies. Half-life estimates of both CD4+ and CD8+ memory T cells were approximated at 200 days. CD4+ and CD8+ T cells were observed to target different SARS-CoV-2 antigens, with CD8+ responses largely targeting the nucleocapsid protein and CD4+ response equally targeting several SARS-CoV-2 proteins.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Cohen et al.\u00a0(Apr 27, 2021). Longitudinal Analysis Shows Durable and Broad Immune Memory after SARS-CoV-2 Infection with Persisting Antibody Responses and Memory B and T Cells. Pre-print downloaded Apr 28 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.04.19.21255739\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.04.19.21255739<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Longitudinal assessment of immune memory response found that SARS-CoV-2 antibodies exhibited an initial rapid decline from peak levels followed by a much slower decrease (\u201cplateau-phase\u201d). Among 254 recovered COVID-19 patients up to 8 months after symptom onset, anti-spike IgG antibodies were estimated to have an initial half-life of 126 days up to&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/28\/longitudinal-analysis-shows-durable-and-broad-immune-memory-after-sars-cov-2-infection-with-persisting-antibody-responses-and-memory-b-and-t-cells\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-9463","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9463"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9463\/revisions"}],"predecessor-version":[{"id":9464,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9463\/revisions\/9464"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9463"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}