{"id":9501,"date":"2021-04-29T17:02:54","date_gmt":"2021-04-30T00:02:54","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9501"},"modified":"2021-04-30T17:03:44","modified_gmt":"2021-05-01T00:03:44","slug":"maternal-antibody-response-neutralizing-potency-and-placental-antibody-transfer-after-severe-acute-respiratory-syndrome-coronavirus-sars-cov-2-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/29\/maternal-antibody-response-neutralizing-potency-and-placental-antibody-transfer-after-severe-acute-respiratory-syndrome-coronavirus-sars-cov-2-infection\/","title":{"rendered":"Maternal Antibody Response, Neutralizing Potency, and Placental Antibody Transfer After Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) Infection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Among maternal blood samples from SARS-CoV-2 positive patients obtained after delivery (n=32), higher median anti-RBD IgG titers were significantly associated with symptomatic (vs. asymptomatic) infection but not with having a PCR-positive test more than 14 days earlier (vs. PCR-positive test within 14 days). Paired cord blood samples also obtained after delivery show that median cord\/maternal anti-RBD IgG antibody ratio was 0.81. Neutralizing antibodies were detected in 94% of maternal blood samples, but only in 25% of cord blood samples. The authors note the efficiency of transplacental antibody transfer was lower than expected.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Joseph et al.\u00a0(Apr 28, 2021). Maternal Antibody Response, Neutralizing Potency, and Placental Antibody Transfer After Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) Infection. Obstetrics &amp; Gynecology. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1097\/AOG.0000000000004440\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1097\/AOG.0000000000004440<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Among maternal blood samples from SARS-CoV-2 positive patients obtained after delivery (n=32), higher median anti-RBD IgG titers were significantly associated with symptomatic (vs. asymptomatic) infection but not with having a PCR-positive test more than 14 days earlier (vs. PCR-positive test within 14 days). Paired cord blood samples also obtained after delivery show that median cord\/maternal&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/29\/maternal-antibody-response-neutralizing-potency-and-placental-antibody-transfer-after-severe-acute-respiratory-syndrome-coronavirus-sars-cov-2-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,32,111,50],"topic":[31],"class_list":["post-9501","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-immunity","tag-infant","tag-pregnancy","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9501"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9501\/revisions"}],"predecessor-version":[{"id":9502,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9501\/revisions\/9502"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9501"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}