{"id":9526,"date":"2021-04-30T09:51:32","date_gmt":"2021-04-30T16:51:32","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9526"},"modified":"2021-05-04T09:52:17","modified_gmt":"2021-05-04T16:52:17","slug":"factors-influencing-the-efficacy-of-covid-19-vaccines-a-quantitative-synthesis-of-phase-iii-trials","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/30\/factors-influencing-the-efficacy-of-covid-19-vaccines-a-quantitative-synthesis-of-phase-iii-trials\/","title":{"rendered":"Factors Influencing the Efficacy of COVID-19 Vaccines: A Quantitative Synthesis of Phase III Trials"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A meta-analysis of efficacy data from Phase III trials of the Pfizer-BioNTech, Moderna, AstraZeneca, and Sputnik V vaccines found that type of vaccine, age and sex of recipients, and the underlying rate of COVID-19 in the study populations did not affect vaccine efficacy. The meta-regression calculated lower efficacy point estimates for the mRNA vaccines among older age groups without a statistically significant test for effect modification.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Calzetta et al. (Apr 1, 2021). Factors Influencing the Efficacy of COVID-19 Vaccines: A Quantitative Synthesis of Phase III Trials. Vaccines. <\/span><\/i><a href=\"https:\/\/doi.org\/10.3390\/vaccines9040341\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.3390\/vaccines9040341<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A meta-analysis of efficacy data from Phase III trials of the Pfizer-BioNTech, Moderna, AstraZeneca, and Sputnik V vaccines found that type of vaccine, age and sex of recipients, and the underlying rate of COVID-19 in the study populations did not affect vaccine efficacy. The meta-regression calculated lower efficacy point estimates for the mRNA vaccines among&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/30\/factors-influencing-the-efficacy-of-covid-19-vaccines-a-quantitative-synthesis-of-phase-iii-trials\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[33],"topic":[31],"class_list":["post-9526","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9526"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9526\/revisions"}],"predecessor-version":[{"id":9527,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9526\/revisions\/9527"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9526"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}