{"id":9530,"date":"2021-04-30T09:53:16","date_gmt":"2021-04-30T16:53:16","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9530"},"modified":"2021-05-04T09:54:03","modified_gmt":"2021-05-04T16:54:03","slug":"previously-infected-vaccinees-broadly-neutralize-sars-cov-2-variants","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/30\/previously-infected-vaccinees-broadly-neutralize-sars-cov-2-variants\/","title":{"rendered":"Previously Infected Vaccinees Broadly Neutralize SARS-CoV-2 Variants"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> A small study of sera from patients vaccinated with the Pfizer-BioNTech vaccine (N=30) found similar levels of anti-SARS-CoV-2 spike antibodies in persons with and without previous documentation of SARS-CoV-2 infection. Additionally, post-vaccination sera from previously infected persons demonstrated higher neutralizing activity in in-vitro against B.1.1.7, B.1.351 and P.1 compared to previously uninfected persons. There was no significant difference between the post-vaccination neutralizing antibody titers of previously infected participants against B.1.351 and those of uninfected participants against wildtype SARS-CoV-2, suggesting that first-generation COVID-19 vaccines could retain efficacy against variants when administered following infection with wildtype SARS-CoV-2.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Leier et al. (Apr 29, 2021). Previously Infected Vaccinees Broadly Neutralize SARS-CoV-2 Variants. Pre-print downloaded Apr 30 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.04.25.21256049\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.04.25.21256049<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A small study of sera from patients vaccinated with the Pfizer-BioNTech vaccine (N=30) found similar levels of anti-SARS-CoV-2 spike antibodies in persons with and without previous documentation of SARS-CoV-2 infection. Additionally, post-vaccination sera from previously infected persons demonstrated higher neutralizing activity in in-vitro against B.1.1.7, B.1.351 and P.1 compared to previously uninfected&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/04\/30\/previously-infected-vaccinees-broadly-neutralize-sars-cov-2-variants\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-9530","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9530","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9530"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9530\/revisions"}],"predecessor-version":[{"id":9531,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9530\/revisions\/9531"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9530"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}