{"id":9556,"date":"2021-05-03T14:11:53","date_gmt":"2021-05-03T21:11:53","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9556"},"modified":"2021-05-06T14:12:38","modified_gmt":"2021-05-06T21:12:38","slug":"weak-immunogenicity-after-a-single-dose-of-sars-cov-2-mrna-vaccine-in-treated-cancer-patients","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/03\/weak-immunogenicity-after-a-single-dose-of-sars-cov-2-mrna-vaccine-in-treated-cancer-patients\/","title":{"rendered":"Weak Immunogenicity after a Single Dose of SARS-CoV-2 MRNA Vaccine in Treated Cancer Patients"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Nearly half of patients with cancer (CP) at a hospital in France showed no anti-spike <\/span><span style=\"font-weight: 400\">antibody response four weeks after one dose of the Pfizer-BioNTech vaccine, while 100% of healthcare workers (HCW) vaccinated at the same time (between February 17 and March 18, 2021) had developed anti-spike antibodies (seroconversion). Anti-S IgG titers were also significantly higher in HCWs than among seropositive CPs (680\u00a0vs\u00a0315 UA\/mL).\u00a0Age older than 65 (aOR = 3.6) and chemotherapy treatment (aOR = 4.3) were associated with <\/span><span style=\"font-weight: 400\">lack of <\/span><span style=\"font-weight: 400\">seroconversion among CP. No symptomatic COVID-19 cases occurred between the two doses in either CPs or HCWs.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Palich et al.\u00a0(Apr 2021). Weak Immunogenicity after a Single Dose of SARS-CoV-2 MRNA Vaccine in Treated Cancer Patients. Annals of Oncology. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.annonc.2021.04.020\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.annonc.2021.04.020<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nearly half of patients with cancer (CP) at a hospital in France showed no anti-spike antibody response four weeks after one dose of the Pfizer-BioNTech vaccine, while 100% of healthcare workers (HCW) vaccinated at the same time (between February 17 and March 18, 2021) had developed anti-spike antibodies (seroconversion). Anti-S IgG titers were also significantly&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/03\/weak-immunogenicity-after-a-single-dose-of-sars-cov-2-mrna-vaccine-in-treated-cancer-patients\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[142],"topic":[31],"class_list":["post-9556","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9556"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9556\/revisions"}],"predecessor-version":[{"id":9557,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9556\/revisions\/9557"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9556"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}