{"id":9587,"date":"2021-05-04T14:31:18","date_gmt":"2021-05-04T21:31:18","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9587"},"modified":"2021-05-06T14:31:53","modified_gmt":"2021-05-06T21:31:53","slug":"sars-cov-2-t-cell-immunity-to-variants-of-concern-following-vaccination","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/04\/sars-cov-2-t-cell-immunity-to-variants-of-concern-following-vaccination\/","title":{"rendered":"SARS -CoV-2 T-Cell Immunity to Variants of Concern Following Vaccination"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> A study using two standardized, functional assays to measure memory T cell immunity to SARS-CoV-2 found that individuals vaccinated with the COVID-19 mRNA vaccines (n=29) mounted a more robust T cell response than convalescent patients (n=19) or healthy controls with no prior infection (n=25). The assay was based upon the \u201cQuantiferon Gold\u201d test for tuberculosis and measured secreted interferon gamma. T cell responses among vaccinated individuals to variants of concern B.1.1.7, B.1.351, and B.1.1.248 were detected but diminished, with median responses lower though not statistically significant among those receiving the Pfizer-BioNTech vaccine than the Moderna vaccine.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Gallagher et al.\u00a0(May 3, 2021). SARS -CoV-2 T-Cell Immunity to Variants of Concern Following Vaccination. Pre-print downloaded May 4 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.03.442455\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.03.442455<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A study using two standardized, functional assays to measure memory T cell immunity to SARS-CoV-2 found that individuals vaccinated with the COVID-19 mRNA vaccines (n=29) mounted a more robust T cell response than convalescent patients (n=19) or healthy controls with no prior infection (n=25). The assay was based upon the \u201cQuantiferon Gold\u201d&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/04\/sars-cov-2-t-cell-immunity-to-variants-of-concern-following-vaccination\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,159],"topic":[31],"class_list":["post-9587","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9587"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9587\/revisions"}],"predecessor-version":[{"id":9588,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9587\/revisions\/9588"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9587"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}