{"id":9634,"date":"2021-05-06T16:59:48","date_gmt":"2021-05-06T23:59:48","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9634"},"modified":"2021-05-07T17:00:39","modified_gmt":"2021-05-08T00:00:39","slug":"bnt162b2-mrna-covid-19-vaccine-induces-antibodies-of-broader-cross-reactivity-than-natural-infection-but-recognition-of-mutant-viruses-is-up-to-10-fold-reduced-2","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/06\/bnt162b2-mrna-covid-19-vaccine-induces-antibodies-of-broader-cross-reactivity-than-natural-infection-but-recognition-of-mutant-viruses-is-up-to-10-fold-reduced-2\/","title":{"rendered":"BNT162b2 MRNA COVID-19 Vaccine Induces Antibodies of Broader Cross-reactivity than Natural Infection but Recognition of Mutant Viruses Is up to 10-fold Reduced"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Antibodies induced by the Pfizer-BioNTech vaccine had higher binding capacities (avidity) than antibodies induced by natural infection against the receptor binding domain (RBD) containing mutations representative of circulating SARS-CoV-2 variants of concern (N501Y, K417N, E484K, and a combination of all three).\u00a0 Vaccine-induced sera (n=6) had 2.5- to 3-fold reduced binding to a RBD containing the N501Y and K417 mutations when compared to a wild type RBD. Of note, both the RBD with E484K mutation and RBD with all three mutations reduced binding by 10-fold, indicating that E484K mutation (found in the B.1.351 and P.1 variant but not in the B.1.1.7 variant) substantially reduces antibody binding.<\/span><i><span style=\"font-weight: 400\"> [EDITORIAL NOTE: An earlier version of this manuscript was summarized as a pre-print in the report on March 16, 2021].<\/span><\/i><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Chang et al.\u00a0(May 5, 2021). BNT162b2 MRNA COVID-19 Vaccine Induces Antibodies of Broader Cross-reactivity than Natural Infection but Recognition of Mutant Viruses Is up to 10-fold Reduced. Allergy. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1111\/all.14893\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1111\/all.14893<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antibodies induced by the Pfizer-BioNTech vaccine had higher binding capacities (avidity) than antibodies induced by natural infection against the receptor binding domain (RBD) containing mutations representative of circulating SARS-CoV-2 variants of concern (N501Y, K417N, E484K, and a combination of all three).\u00a0 Vaccine-induced sera (n=6) had 2.5- to 3-fold reduced binding to a RBD containing the&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/06\/bnt162b2-mrna-covid-19-vaccine-induces-antibodies-of-broader-cross-reactivity-than-natural-infection-but-recognition-of-mutant-viruses-is-up-to-10-fold-reduced-2\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[67,33],"topic":[31],"class_list":["post-9634","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-antibodies","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9634"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9634\/revisions"}],"predecessor-version":[{"id":9635,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9634\/revisions\/9635"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9634"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}