{"id":9684,"date":"2021-05-10T15:30:52","date_gmt":"2021-05-10T22:30:52","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9684"},"modified":"2021-05-12T15:31:37","modified_gmt":"2021-05-12T22:31:37","slug":"precision-health-diagnostic-and-surveillance-network-uses-s-gene-target-failure-sgtf-combined-with-sequencing-technologies-to-identify-emerging-sars-cov-2-variants","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/10\/precision-health-diagnostic-and-surveillance-network-uses-s-gene-target-failure-sgtf-combined-with-sequencing-technologies-to-identify-emerging-sars-cov-2-variants\/","title":{"rendered":"Precision Health Diagnostic and Surveillance Network Uses S Gene Target Failure (SGTF) Combined with Sequencing Technologies to Identify Emerging SARS-CoV-2 Variants"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> A<\/span><span style=\"font-weight: 400\"> genomic surveillance algorithm developed to combine RT-PCR and sequencing technologies to identify SARS-CoV-2 variants of concern found <\/span><span style=\"font-weight: 400\">the<\/span><span style=\"font-weight: 400\"> frequency of S Gene Target Failure (SGTF) <\/span><span style=\"font-weight: 400\">exponentially to 47% and 48% by <\/span><span style=\"font-weight: 400\">the last week of March 2021, in both Puerto Rico and US laboratories, respectively. <\/span><span style=\"font-weight: 400\">SGTF is used as a proxy for the SARS-CoV-2 B.1.1.7 variant. <\/span><span style=\"font-weight: 400\">This increase in SGTF prevalence was concurrent with an increase in variants of concern among all SARS-CoV-2 sequences from Puerto Rico uploaded to GISAID (n = 461). The frequency of the B.1.1.7 variant increased from &lt;1% in the last week of January 2021 to 51.5% of viral sequences from Puerto Rico collected in the last week of March 2021.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Guerrero-Preston et al.\u00a0(May 7, 2021). Precision Health Diagnostic and Surveillance Network Uses S Gene Target Failure (SGTF) Combined with Sequencing Technologies to Identify Emerging SARS-CoV-2 Variants. Pre-print downloaded May 10 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.04.21256012\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.04.21256012<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] A genomic surveillance algorithm developed to combine RT-PCR and sequencing technologies to identify SARS-CoV-2 variants of concern found the frequency of S Gene Target Failure (SGTF) exponentially to 47% and 48% by the last week of March 2021, in both Puerto Rico and US laboratories, respectively. SGTF is used as a proxy&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/10\/precision-health-diagnostic-and-surveillance-network-uses-s-gene-target-failure-sgtf-combined-with-sequencing-technologies-to-identify-emerging-sars-cov-2-variants\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[27,159],"topic":[19],"class_list":["post-9684","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-testing","tag-variants","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9684"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9684\/revisions"}],"predecessor-version":[{"id":9685,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9684\/revisions\/9685"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9684"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}