{"id":9688,"date":"2021-05-10T15:32:29","date_gmt":"2021-05-10T22:32:29","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9688"},"modified":"2021-05-12T15:33:06","modified_gmt":"2021-05-12T22:33:06","slug":"performance-of-three-sars-cov-2-immunoassays-three-rapid-lateral-flow-tests-and-a-novel-bead-based-affinity-surrogate-test-for-the-detection-of-sars-cov-2-antibodies-in-human-serum","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/10\/performance-of-three-sars-cov-2-immunoassays-three-rapid-lateral-flow-tests-and-a-novel-bead-based-affinity-surrogate-test-for-the-detection-of-sars-cov-2-antibodies-in-human-serum\/","title":{"rendered":"Performance of Three SARS-CoV-2 Immunoassays, Three Rapid Lateral Flow Tests and a Novel Bead-Based Affinity Surrogate Test for the Detection of SARS-CoV-2 Antibodies in Human Serum"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A study comparing the performance of three commercial immunoassays to detect SARS-CoV-2 IgA and IgG antibodies (Euroimmun SARS-COV-2 IgA\/IgG, Mikrogen\u00a0<\/span><i><span style=\"font-weight: 400\">recom<\/span><\/i><span style=\"font-weight: 400\">Well SARS-CoV-2 IgA\/IgG, and SERION ELISA\u00a0<\/span><i><span style=\"font-weight: 400\">agile<\/span><\/i><span style=\"font-weight: 400\">\u00a0SARS-CoV-2 IgA\/IgG) and three rapid lateral flow tests (Abbott Panbio COVID-19 IgG\/IgM, NADAL COVID-19 IgG\/IgM, and Cleartest Corona 2019-nCOV IgG\/IgM) to a gold standard plaque-reduction neutralization test (PRNT50) found that the sensitivity of the three immunoassays ranged from 32% to 91%, and the specificity from 86% to 100%. The lowest sensitivity among the immunoassays was a test for IgA. The lateral flow assays had a broader range of sensitivity (7-89%) and similar specificity (91-100%). Only the SERION IgG showed a sensitivity and specificity of &gt;98%. The analysis was based on samples from 63 patients who recovered from COVID-19 up to seven months after symptom onset, and 50 samples from before the beginning of the pandemic.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Krone et al.\u00a0(May 7, 2021). Performance of Three SARS-CoV-2 Immunoassays, Three Rapid Lateral Flow Tests and a Novel Bead-Based Affinity Surrogate Test for the Detection of SARS-CoV-2 Antibodies in Human Serum. Journal of Clinical Microbiology. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1128\/JCM.00319-21\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1128\/JCM.00319-21<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study comparing the performance of three commercial immunoassays to detect SARS-CoV-2 IgA and IgG antibodies (Euroimmun SARS-COV-2 IgA\/IgG, Mikrogen\u00a0recomWell SARS-CoV-2 IgA\/IgG, and SERION ELISA\u00a0agile\u00a0SARS-CoV-2 IgA\/IgG) and three rapid lateral flow tests (Abbott Panbio COVID-19 IgG\/IgM, NADAL COVID-19 IgG\/IgM, and Cleartest Corona 2019-nCOV IgG\/IgM) to a gold standard plaque-reduction neutralization test (PRNT50) found that the&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/10\/performance-of-three-sars-cov-2-immunoassays-three-rapid-lateral-flow-tests-and-a-novel-bead-based-affinity-surrogate-test-for-the-detection-of-sars-cov-2-antibodies-in-human-serum\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[27],"topic":[19],"class_list":["post-9688","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-testing","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9688"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9688\/revisions"}],"predecessor-version":[{"id":9689,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9688\/revisions\/9689"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9688"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}