{"id":9696,"date":"2021-05-10T15:35:30","date_gmt":"2021-05-10T22:35:30","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9696"},"modified":"2021-05-12T15:36:14","modified_gmt":"2021-05-12T22:36:14","slug":"vaccination-boosts-naturally-enhanced-neutralizing-breadth-to-sars-cov-2-one-year-after-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/10\/vaccination-boosts-naturally-enhanced-neutralizing-breadth-to-sars-cov-2-one-year-after-infection\/","title":{"rendered":"Vaccination Boosts Naturally Enhanced Neutralizing Breadth to SARS-CoV-2 One Year after Infection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> Among <\/span><span style=\"font-weight: 400\">63 <\/span><span style=\"font-weight: 400\">COVID-19 <\/span><span style=\"font-weight: 400\">convalescent individuals assessed at 1.3, 6.2 and 12 months after infection<\/span><span style=\"font-weight: 400\">,<\/span><span style=\"font-weight: 400\"> antibody reactivity to the receptor binding domain (RBD), neutralizing activity, and the number of RBD-specific memory B cells remained relatively stable from 6 to 12 months<\/span><span style=\"font-weight: 400\"> in those who had not been vaccinated. Among the 41% of the cohort who <\/span><span style=\"font-weight: 400\">received an mRNA vaccine<\/span><span style=\"font-weight: 400\">, <\/span><span style=\"font-weight: 400\">all components of the humoral response were increased, and serum neutralizing activit<\/span><span style=\"font-weight: 400\">y<\/span><span style=\"font-weight: 400\"> against variants of concern <\/span><span style=\"font-weight: 400\">was <\/span><span style=\"font-weight: 400\">comparable to or greater than the original strain achieved by vaccination of individuals not previously infected. The authors argue that immunity among convalescent individuals may be long lasting, and that those who receive mRNA vaccines will produce antibodies and memory B cells that may be protective against circulating SARS-CoV-2 variants.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Wang et al. (May 9, 2021). Vaccination Boosts Naturally Enhanced Neutralizing Breadth to SARS-CoV-2 One Year after Infection. Pre-print downloaded May 10 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.07.443175\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.07.443175<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Among 63 COVID-19 convalescent individuals assessed at 1.3, 6.2 and 12 months after infection, antibody reactivity to the receptor binding domain (RBD), neutralizing activity, and the number of RBD-specific memory B cells remained relatively stable from 6 to 12 months in those who had not been vaccinated. Among the 41% of the&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/10\/vaccination-boosts-naturally-enhanced-neutralizing-breadth-to-sars-cov-2-one-year-after-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,159],"topic":[31],"class_list":["post-9696","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9696"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9696\/revisions"}],"predecessor-version":[{"id":9697,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9696\/revisions\/9697"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9696"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}