{"id":9700,"date":"2021-05-10T15:37:19","date_gmt":"2021-05-10T22:37:19","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9700"},"modified":"2021-05-12T15:38:09","modified_gmt":"2021-05-12T22:38:09","slug":"reverse-transcribed-sars-cov-2-rna-can-integrate-into-the-genome-of-cultured-human-cells-and-can-be-expressed-in-patient-derived-tissues","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/10\/reverse-transcribed-sars-cov-2-rna-can-integrate-into-the-genome-of-cultured-human-cells-and-can-be-expressed-in-patient-derived-tissues\/","title":{"rendered":"Reverse-Transcribed SARS-CoV-2 RNA Can Integrate into the Genome of Cultured Human Cells and Can Be Expressed in Patient-Derived Tissues"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A study using RNA sequencing found evidence to suggest that SARS-CoV-2 RNA may be able to integrate into human cell genomes in vitro, perhaps explaining the persistence of viral RNA among patients even after recovery from COVID-19. The authors found <\/span><span style=\"font-weight: 400\">evidence <\/span><span style=\"font-weight: 400\">that <\/span><span style=\"font-weight: 400\">suggest<\/span><span style=\"font-weight: 400\">s<\/span><span style=\"font-weight: 400\"> viral\u2013host chimeric transcripts <\/span><span style=\"font-weight: 400\">are created <\/span><span style=\"font-weight: 400\">via long interspersed nuclear elements, which reverse-transcribe RNA into DNA.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Zhang et al.\u00a0(May 25, 2021). Reverse-Transcribed SARS-CoV-2 RNA Can Integrate into the Genome of Cultured Human Cells and Can Be Expressed in Patient-Derived Tissues. Proceedings of the National Academy of Sciences. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1073\/pnas.2105968118\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1073\/pnas.2105968118<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study using RNA sequencing found evidence to suggest that SARS-CoV-2 RNA may be able to integrate into human cell genomes in vitro, perhaps explaining the persistence of viral RNA among patients even after recovery from COVID-19. The authors found evidence that suggests viral\u2013host chimeric transcripts are created via long interspersed nuclear elements, which reverse-transcribe&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/10\/reverse-transcribed-sars-cov-2-rna-can-integrate-into-the-genome-of-cultured-human-cells-and-can-be-expressed-in-patient-derived-tissues\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[34],"topic":[20],"class_list":["post-9700","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-clinical-characteristics","topic-clinical-characteristics-and-health-care-setting"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9700"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9700\/revisions"}],"predecessor-version":[{"id":9701,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9700\/revisions\/9701"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9700"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}