{"id":9741,"date":"2021-05-12T10:31:18","date_gmt":"2021-05-12T17:31:18","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9741"},"modified":"2021-05-13T10:32:15","modified_gmt":"2021-05-13T17:32:15","slug":"sars-cov-2-infectivity-by-viral-load-s-gene-variants-and-demographic-factors-and-the-utility-of-lateral-flow-devices-to-prevent-transmission","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/12\/sars-cov-2-infectivity-by-viral-load-s-gene-variants-and-demographic-factors-and-the-utility-of-lateral-flow-devices-to-prevent-transmission\/","title":{"rendered":"SARS-CoV-2 Infectivity by Viral Load, S Gene Variants and Demographic Factors and the Utility of Lateral Flow Devices to Prevent Transmission"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">SARS-CoV-2 index cases with lower PCR cycle threshold (Ct) values (suggesting a higher viral load) tended to have a higher proportion of contacts infected with SARS-CoV2, according to a study combining testing and contact tracing data from England between September 2020 and February 2021. Attack rates were 12% for index cases with Ct=15 and 5% for index cases with Ct=30. Attack rates were 55% higher among index cases with infections with S gene target failure (a known proxy for the B.1.1.7 variant). Attack rates were highest among household contacts (9%) followed by household visitors (7%), and lower among outdoor contacts (3%) and work\/education contacts (5%). Contacts of children were the least likely to test positive, particularly following contact outdoors or at work\/educational settings.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Lee et al.\u00a0(May 11, 2021). SARS-CoV-2 Infectivity by Viral Load, S Gene Variants and Demographic Factors and the Utility of Lateral Flow Devices to Prevent Transmission. Clinical Infectious Diseases. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciab421\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1093\/cid\/ciab421<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>SARS-CoV-2 index cases with lower PCR cycle threshold (Ct) values (suggesting a higher viral load) tended to have a higher proportion of contacts infected with SARS-CoV2, according to a study combining testing and contact tracing data from England between September 2020 and February 2021. Attack rates were 12% for index cases with Ct=15 and 5%&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/12\/sars-cov-2-infectivity-by-viral-load-s-gene-variants-and-demographic-factors-and-the-utility-of-lateral-flow-devices-to-prevent-transmission\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[38,159],"topic":[21],"class_list":["post-9741","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-transmission","tag-variants","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9741"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9741\/revisions"}],"predecessor-version":[{"id":9742,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9741\/revisions\/9742"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9741"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}