{"id":9745,"date":"2021-05-12T10:33:09","date_gmt":"2021-05-12T17:33:09","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9745"},"modified":"2021-05-13T10:34:40","modified_gmt":"2021-05-13T17:34:40","slug":"a-randomized-double-blind-controlled-trial-of-convalescent-plasma-in-adults-with-severe-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/12\/a-randomized-double-blind-controlled-trial-of-convalescent-plasma-in-adults-with-severe-covid-19\/","title":{"rendered":"A Randomized Double-Blind Controlled Trial of Convalescent Plasma in Adults with Severe COVID-19"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Participants with severe COVID-19 randomized to receive convalescent plasma (n=150) had significantly lower 28-day mortality (OR=0.44, 95% CI: 0.22-.91) compared to those receiving controlled plasma (n=73) in a randomized double-blind controlled trial conducted in New York and Brazil. However, no significant improvement in clinical status, as measured on an ordinal scale, was observed at 28 days (OR=1.50, 95% CI: 0.83-2.68) and the authors caution that the difference in mortality was not observed in larger inpatient trials explicitly designed to test for effects on mortality. The median titer of anti-SARS-CoV-2 neutralizing antibody in infused convalescent plasma units was 1:160. No evidence of SARS-CoV-2 variants linked with neutralization escape was found in a subset of samples from Brazil.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">O\u2019Donnell et al.\u00a0(May 11, 2021). A Randomized Double-Blind Controlled Trial of Convalescent Plasma in Adults with Severe COVID-19. Journal of Clinical Investigation. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1172\/JCI150646\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1172\/JCI150646<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Participants with severe COVID-19 randomized to receive convalescent plasma (n=150) had significantly lower 28-day mortality (OR=0.44, 95% CI: 0.22-.91) compared to those receiving controlled plasma (n=73) in a randomized double-blind controlled trial conducted in New York and Brazil. However, no significant improvement in clinical status, as measured on an ordinal scale, was observed at 28&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/12\/a-randomized-double-blind-controlled-trial-of-convalescent-plasma-in-adults-with-severe-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-9745","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9745","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9745"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9745\/revisions"}],"predecessor-version":[{"id":9746,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9745\/revisions\/9746"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9745"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9745"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9745"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9745"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}