{"id":9747,"date":"2021-05-12T10:34:47","date_gmt":"2021-05-12T17:34:47","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9747"},"modified":"2021-05-13T10:35:25","modified_gmt":"2021-05-13T17:35:25","slug":"remdesivir-for-coronavirus-disease-2019-covid-19-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/12\/remdesivir-for-coronavirus-disease-2019-covid-19-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials\/","title":{"rendered":"Remdesivir for Coronavirus Disease 2019 (COVID-19): A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">A systematic review and meta-analysis of 5 randomized placebo-controlled trials (n=7,540 total participants) found no significant evidence that remdesivir (100 mg over 10 days) reduced all-cause mortality (RR=0.94, CI 0.82-1.07), clinical progression (RR=1.08, CI 0.99-1.18), or diarrhea (RR=0.82, CI 0.40-1.66). The authors conducted a trial sequential analysis and found that the meta-analysis was underpowered to detect a 10% reduction in all-cause mortality at 0% sample heterogeneity and 11% baseline risk (required n=24,281).<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Okoli et al.\u00a0(May 11, 2021). Remdesivir for Coronavirus Disease 2019 (COVID-19): A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. Infectious Diseases. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1080\/23744235.2021.1923799\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1080\/23744235.2021.1923799<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A systematic review and meta-analysis of 5 randomized placebo-controlled trials (n=7,540 total participants) found no significant evidence that remdesivir (100 mg over 10 days) reduced all-cause mortality (RR=0.94, CI 0.82-1.07), clinical progression (RR=1.08, CI 0.99-1.18), or diarrhea (RR=0.82, CI 0.40-1.66). The authors conducted a trial sequential analysis and found that the meta-analysis was underpowered to&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/12\/remdesivir-for-coronavirus-disease-2019-covid-19-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-9747","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9747","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9747"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9747\/revisions"}],"predecessor-version":[{"id":9748,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9747\/revisions\/9748"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9747"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9747"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9747"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}