{"id":9753,"date":"2021-05-12T10:37:28","date_gmt":"2021-05-12T17:37:28","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9753"},"modified":"2021-05-13T10:38:12","modified_gmt":"2021-05-13T17:38:12","slug":"passive-and-active-immunity-in-infants-born-to-mothers-with-sars-cov-2-infection-during-pregnancy-prospective-cohort-study","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/12\/passive-and-active-immunity-in-infants-born-to-mothers-with-sars-cov-2-infection-during-pregnancy-prospective-cohort-study\/","title":{"rendered":"Passive and Active Immunity in Infants Born to Mothers with SARS-CoV-2 Infection during Pregnancy: Prospective Cohort Study"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> In a cohort of US mothers testing positive for SARS-CoV-2 during pregnancy (n=145), anti-SARS-CoV-2 antibodies were detected in 65% and 58% of maternal and cord blood samples at delivery, respectively. The IgG transplacental transfer ratio was significantly higher among women receiving their first maternal positive PCR test 60-180 days before delivery compared to those receiving their first test &lt;60 days before delivery (ratio 1.2 vs 0.6). Infants were followed with serial serologic analysis and 2 of 147 infants seroconverted (defined as high levels of IgG and IgM) by as early as 2 weeks, including one premature infant with confirmed intrapartum infection. IgG antibody levels in the infants correlated with IgG levels in the cord blood. In infants with maternally derived antibody, 8% (4 of 48) became undetectable at 1-4 weeks and 38% (5 of 14) were undetectable by 13-28 weeks, with some antibodies persisting up to 6 months of age.\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Song et al.\u00a0(May 3, 2021). Passive and Active Immunity in Infants Born to Mothers with SARS-CoV-2 Infection during Pregnancy: Prospective Cohort Study. Pre-print downloaded May 12 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.01.21255871\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.01.21255871<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] In a cohort of US mothers testing positive for SARS-CoV-2 during pregnancy (n=145), anti-SARS-CoV-2 antibodies were detected in 65% and 58% of maternal and cord blood samples at delivery, respectively. The IgG transplacental transfer ratio was significantly higher among women receiving their first maternal positive PCR test 60-180 days before delivery compared&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/12\/passive-and-active-immunity-in-infants-born-to-mothers-with-sars-cov-2-infection-during-pregnancy-prospective-cohort-study\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,50],"topic":[31],"class_list":["post-9753","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-pregnancy","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9753","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9753"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9753\/revisions"}],"predecessor-version":[{"id":9754,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9753\/revisions\/9754"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9753"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}