{"id":9777,"date":"2021-05-13T14:12:49","date_gmt":"2021-05-13T21:12:49","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9777"},"modified":"2021-05-14T14:13:28","modified_gmt":"2021-05-14T21:13:28","slug":"mrna-vaccine-induced-sars-cov-2-specific-t-cells-recognize-b-1-1-7-and-b-1-351-variants-but-differ-in-longevity-and-homing-properties-depending-on-prior-infection-status","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/13\/mrna-vaccine-induced-sars-cov-2-specific-t-cells-recognize-b-1-1-7-and-b-1-351-variants-but-differ-in-longevity-and-homing-properties-depending-on-prior-infection-status\/","title":{"rendered":"mRNA Vaccine-Induced SARS-CoV-2-Specific T Cells Recognize B.1.1.7 and B.1.351 Variants but Differ in Longevity and Homing Properties Depending on Prior Infection Status"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> CD4+ T cell responses elicited by COVID-19 mRNA vaccines respond similarly to spike protein epitopes derived from the SARS-CoV-2 B.1.1.7 and B.1.351 variants of concern and the ancestral strain, based on an analysis of 24 specimens obtained at 3 different timepoints from 8 fully vaccinated individuals. The second vaccine dose appeared to elicit a quantitative increase of spike-specific T cells in individuals without prior infection (n=4), but not in those with prior infection (n=4). Regardless of history of infection, the second dose did not change T cell phenotype. The authors conclude that T cell phenotype among those with prior infection indicates superior long-term persistence as compared to those without prior infection.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Neidleman et al.\u00a0(May 12, 2021). mRNA Vaccine-Induced SARS-CoV-2-Specific T Cells Recognize B.1.1.7 and B.1.351 Variants but Differ in Longevity and Homing Properties Depending on Prior Infection Status. Pre-print downloaded May 13 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.12.443888\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.12.443888<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] CD4+ T cell responses elicited by COVID-19 mRNA vaccines respond similarly to spike protein epitopes derived from the SARS-CoV-2 B.1.1.7 and B.1.351 variants of concern and the ancestral strain, based on an analysis of 24 specimens obtained at 3 different timepoints from 8 fully vaccinated individuals. The second vaccine dose appeared to&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/13\/mrna-vaccine-induced-sars-cov-2-specific-t-cells-recognize-b-1-1-7-and-b-1-351-variants-but-differ-in-longevity-and-homing-properties-depending-on-prior-infection-status\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[142,159],"topic":[31],"class_list":["post-9777","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine","tag-variants","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9777"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9777\/revisions"}],"predecessor-version":[{"id":9778,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9777\/revisions\/9778"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9777"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}