{"id":9810,"date":"2021-05-14T11:47:48","date_gmt":"2021-05-14T18:47:48","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9810"},"modified":"2021-05-17T11:48:28","modified_gmt":"2021-05-17T18:48:28","slug":"bnt162b2-elicited-neutralization-against-new-sars-cov-2-spike-variants","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/14\/bnt162b2-elicited-neutralization-against-new-sars-cov-2-spike-variants\/","title":{"rendered":"BNT162b2-Elicited Neutralization against New SARS-CoV-2 Spike Variants"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">An <\/span><i><span style=\"font-weight: 400\">in vitro<\/span><\/i><span style=\"font-weight: 400\"> study of serum neutralization after two doses of Pfizer-BioNTech vaccine found that variants B.1.526, B.1.429, and B.1.1.7+E484K remained susceptible to vaccine-elicited neutralizing antibodies at a level equivalent to the neutralization of wild-type USA-WA1\/2020 strain. The authors suggest that these results indicate the additional E484K mutation, also found in the B.1.351 and B.1.526 lineages, causes little compromise to neutralization of vaccine-induced antibodies and confirm the importance of mass immunization as a central strategy to control the COVID-19 pandemic.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Liu et al. (May 12, 2021). BNT162b2-Elicited Neutralization against New SARS-CoV-2 Spike Variants. New England Journal of Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1056\/NEJMc2106083\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1056\/NEJMc2106083<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An in vitro study of serum neutralization after two doses of Pfizer-BioNTech vaccine found that variants B.1.526, B.1.429, and B.1.1.7+E484K remained susceptible to vaccine-elicited neutralizing antibodies at a level equivalent to the neutralization of wild-type USA-WA1\/2020 strain. The authors suggest that these results indicate the additional E484K mutation, also found in the B.1.351 and B.1.526&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/14\/bnt162b2-elicited-neutralization-against-new-sars-cov-2-spike-variants\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[142,141],"topic":[31],"class_list":["post-9810","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine","tag-variant","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9810","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9810"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9810\/revisions"}],"predecessor-version":[{"id":9811,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9810\/revisions\/9811"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9810"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9810"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9810"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}