{"id":9842,"date":"2021-05-17T10:15:13","date_gmt":"2021-05-17T17:15:13","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9842"},"modified":"2021-05-18T10:15:57","modified_gmt":"2021-05-18T17:15:57","slug":"cellular-immunity-predominates-over-humoral-immunity-after-the-first-dose-of-covid-19-vaccines-in-solid-organ-transplant-recipients","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/17\/cellular-immunity-predominates-over-humoral-immunity-after-the-first-dose-of-covid-19-vaccines-in-solid-organ-transplant-recipients\/","title":{"rendered":"Cellular Immunity Predominates over Humoral Immunity after the First Dose of COVID-19 Vaccines in Solid Organ Transplant Recipients"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> Among solid organ transplant recipients (n = 40) and age-matched controls (n = 70), <\/span><span style=\"font-weight: 400\">antibodies were detected in only <\/span><span style=\"font-weight: 400\">5% of<\/span><span style=\"font-weight: 400\"> transplant recipients versus 80% of controls, though specific CD4 and\/or CD8 T-cells were more frequently found in both transplant recipients <\/span><span style=\"font-weight: 400\">(24<\/span><span style=\"font-weight: 400\">%) and controls (84%)<\/span><span style=\"font-weight: 400\">.<\/span><span style=\"font-weight: 400\"> IgG and neutralization activity were also higher after vaccination with one of the mRNA vaccines compared to the Oxford-AstraZeneca vaccine, while CD4 and CD8 T-cell levels were higher after the Oxford-AstraZeneca vaccine. The authors <\/span><span style=\"font-weight: 400\">suggest <\/span><span style=\"font-weight: 400\">that antibody assessments alone are not sufficient to identify a vaccine response, and analyses of both humoral and cellular immunity will be important.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Schmidt et al.\u00a0(May 14, 2021). Cellular Immunity Predominates over Humoral Immunity after the First Dose of COVID-19 Vaccines in Solid Organ Transplant Recipients. Pre-print downloaded May 17 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.07.21256809\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.07.21256809<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Among solid organ transplant recipients (n = 40) and age-matched controls (n = 70), antibodies were detected in only 5% of transplant recipients versus 80% of controls, though specific CD4 and\/or CD8 T-cells were more frequently found in both transplant recipients (24%) and controls (84%). IgG and neutralization activity were also higher&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/17\/cellular-immunity-predominates-over-humoral-immunity-after-the-first-dose-of-covid-19-vaccines-in-solid-organ-transplant-recipients\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[142],"topic":[31],"class_list":["post-9842","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-vaccine","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9842"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9842\/revisions"}],"predecessor-version":[{"id":9843,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9842\/revisions\/9843"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9842"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}