{"id":9873,"date":"2021-05-18T10:21:36","date_gmt":"2021-05-18T17:21:36","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9873"},"modified":"2021-05-19T10:28:19","modified_gmt":"2021-05-19T17:28:19","slug":"decay-of-fc-dependent-antibody-functions-after-mild-to-moderate-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/18\/decay-of-fc-dependent-antibody-functions-after-mild-to-moderate-covid-19\/","title":{"rendered":"Decay of Fc-Dependent Antibody Functions after Mild to Moderate COVID-19"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Antibody effector functions associated with opsonization and killing of infected cells declined over time in a cohort of 58 subjects recovering from mild-to-moderate COVID-19. Levels of anti-SARS-CoV-2 spike (S) antibodies with Fcy receptors, S-specific antibody-dependent cellular cytotoxicity (ADCC), and antibody dependent phagocytosis (ADP) declined from the initial peak in samples drawn ~30-60 days post-symptom onset but remained detectable in 94% of subjects when the last samples were collected at a median of 123 days post-symptom onset.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Lee et al.\u00a0(May 5, 2021). Decay of Fc-Dependent Antibody Functions after Mild to Moderate COVID-19. Cell Reports Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/j.xcrm.2021.100296\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/j.xcrm.2021.100296<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antibody effector functions associated with opsonization and killing of infected cells declined over time in a cohort of 58 subjects recovering from mild-to-moderate COVID-19. Levels of anti-SARS-CoV-2 spike (S) antibodies with Fcy receptors, S-specific antibody-dependent cellular cytotoxicity (ADCC), and antibody dependent phagocytosis (ADP) declined from the initial peak in samples drawn ~30-60 days post-symptom onset&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/18\/decay-of-fc-dependent-antibody-functions-after-mild-to-moderate-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-9873","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9873"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9873\/revisions"}],"predecessor-version":[{"id":9874,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9873\/revisions\/9874"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9873"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9873"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9873"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}