{"id":9904,"date":"2021-05-19T11:44:35","date_gmt":"2021-05-19T18:44:35","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9904"},"modified":"2021-05-20T11:45:25","modified_gmt":"2021-05-20T18:45:25","slug":"neutralizing-antibody-levels-are-highly-predictive-of-immune-protection-from-symptomatic-sars-cov-2-infection","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/19\/neutralizing-antibody-levels-are-highly-predictive-of-immune-protection-from-symptomatic-sars-cov-2-infection\/","title":{"rendered":"Neutralizing Antibody Levels Are Highly Predictive of Immune Protection from Symptomatic SARS-CoV-2 Infection"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Vaccine efficacy of 7 COVID-19 vaccines correlated well with reported vaccine-elicited neutralization titers (r=0.9), according to an analysis of phase 3 vaccine trial data. Using data from the trials and neutralization data from cohorts of convalescent patients, the authors estimated that levels of vaccine-elicited anti-SARS-CoV-2 neutralizing antibodies required for 50% protection against detectable SARS-CoV-2 infection was 20% of the mean convalescent neutralization level among patients with previous infection. Neutralization levels required for 50% protection against severe disease was only 3% of the mean convalescent level. Using modeling to estimate decay of the neutralization titer over the first 250\u2009days after immunization, the authors predict that while vaccine-elicited neutralization levels may decline significantly over time, protection against severe disease may still largely be retained.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Khoury et al.\u00a0(May 17, 2021). Neutralizing Antibody Levels Are Highly Predictive of Immune Protection from Symptomatic SARS-CoV-2 Infection. Nature Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41591-021-01377-8\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1038\/s41591-021-01377-8<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vaccine efficacy of 7 COVID-19 vaccines correlated well with reported vaccine-elicited neutralization titers (r=0.9), according to an analysis of phase 3 vaccine trial data. Using data from the trials and neutralization data from cohorts of convalescent patients, the authors estimated that levels of vaccine-elicited anti-SARS-CoV-2 neutralizing antibodies required for 50% protection against detectable SARS-CoV-2 infection&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/19\/neutralizing-antibody-levels-are-highly-predictive-of-immune-protection-from-symptomatic-sars-cov-2-infection\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32,33],"topic":[31],"class_list":["post-9904","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","tag-vaccines","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9904","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9904"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9904\/revisions"}],"predecessor-version":[{"id":9905,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9904\/revisions\/9905"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9904"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9904"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9904"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9904"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}