{"id":9910,"date":"2021-05-19T11:47:18","date_gmt":"2021-05-19T18:47:18","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9910"},"modified":"2021-05-20T11:48:12","modified_gmt":"2021-05-20T18:48:12","slug":"rapidly-emerging-sars-cov-2-b-1-1-7-sub-lineage-in-the-united-states-of-america-with-spike-protein-d178h-and-membrane-protein-v70l-mutations","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/19\/rapidly-emerging-sars-cov-2-b-1-1-7-sub-lineage-in-the-united-states-of-america-with-spike-protein-d178h-and-membrane-protein-v70l-mutations\/","title":{"rendered":"Rapidly Emerging SARS-CoV-2 B.1.1.7 Sub-Lineage in the United States of America with Spike Protein D178H and Membrane Protein V70L Mutations"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">[Pre-print, not peer-reviewed]<\/span><\/i><span style=\"font-weight: 400\"> Genomic surveillance of SARS-CoV-2 cases identified an expanding US-specific sub-lineage of the B.1.1.7 variant. This sub-lineage is characterized with sequential acquisition of a membrane protein mutation, V20L, in November 2020 and a spike mutation, D178H, in early February 2021. The proportion of B.1.1.7 isolates in the US belonging to this sub-lineage increased from 0.15% in February to 1.8% in April 2021. The sub-lineage comprises 37% of B.1.1.7 isolates in Washington State to date and has also been detected in 30 other states. Phylogenetic analysis suggests the sub-lineage may have originated from either California or Washington, while structural analysis suggests the D178H mutation may affect neutralization capacity of antibodies targeting the N terminal domain.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Shen et al.\u00a0(May 18, 2021). Rapidly Emerging SARS-CoV-2 B.1.1.7 Sub-Lineage in the United States of America with Spike Protein D178H and Membrane Protein V70L Mutations. Pre-print downloaded May 19 from <\/span><\/i><a href=\"https:\/\/doi.org\/10.1101\/2021.05.14.21257247\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1101\/2021.05.14.21257247<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Pre-print, not peer-reviewed] Genomic surveillance of SARS-CoV-2 cases identified an expanding US-specific sub-lineage of the B.1.1.7 variant. This sub-lineage is characterized with sequential acquisition of a membrane protein mutation, V20L, in November 2020 and a spike mutation, D178H, in early February 2021. The proportion of B.1.1.7 isolates in the US belonging to this sub-lineage increased&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/19\/rapidly-emerging-sars-cov-2-b-1-1-7-sub-lineage-in-the-united-states-of-america-with-spike-protein-d178h-and-membrane-protein-v70l-mutations\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[38,159,59,68],"topic":[24],"class_list":["post-9910","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-transmission","tag-variants","tag-wa","tag-washington","topic-geographic-spread"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9910","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9910"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9910\/revisions"}],"predecessor-version":[{"id":9911,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9910\/revisions\/9911"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9910"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9910"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9910"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9910"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}