{"id":9921,"date":"2021-05-20T15:18:51","date_gmt":"2021-05-20T22:18:51","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9921"},"modified":"2021-05-21T15:19:30","modified_gmt":"2021-05-21T22:19:30","slug":"tocilizumab-in-the-treatment-of-covid-19-a-meta-analysis","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/20\/tocilizumab-in-the-treatment-of-covid-19-a-meta-analysis\/","title":{"rendered":"Tocilizumab in the Treatment of COVID-19 &#8211; a Meta-Analysis"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">The immunosuppressive monoclonal antibody treatment tocilizumab (TCZ) was associated with a 11% reduction in risk for all-cause 28- and 30-day mortality compared to placebo\/control in a systematic review and meta-analysis of 8 randomized trials, which included 6,481 patients mostly with severe but non-critical COVID-19. TCZ was also associated with reduced risk of mechanical ventilation, ICU admission, and superinfection. However, no mortality benefit was demonstrated among the subgroup of critically ill patients or in trials where &gt;80% of patients used steroids.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Avni et al.\u00a0(May 19, 2021). Tocilizumab in the Treatment of COVID-19 &#8211; a Meta-Analysis. QJM: An International Journal of Medicine. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1093\/qjmed\/hcab142\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1093\/qjmed\/hcab142<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The immunosuppressive monoclonal antibody treatment tocilizumab (TCZ) was associated with a 11% reduction in risk for all-cause 28- and 30-day mortality compared to placebo\/control in a systematic review and meta-analysis of 8 randomized trials, which included 6,481 patients mostly with severe but non-critical COVID-19. TCZ was also associated with reduced risk of mechanical ventilation, ICU&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/20\/tocilizumab-in-the-treatment-of-covid-19-a-meta-analysis\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[28],"topic":[19],"class_list":["post-9921","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-treatment","topic-testing-and-treatment"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9921"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9921\/revisions"}],"predecessor-version":[{"id":9922,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9921\/revisions\/9922"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9921"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9921"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9921"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}