{"id":9927,"date":"2021-05-20T15:22:04","date_gmt":"2021-05-20T22:22:04","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9927"},"modified":"2021-05-21T15:22:51","modified_gmt":"2021-05-21T22:22:51","slug":"diverse-functional-autoantibodies-in-patients-with-covid-19","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/20\/diverse-functional-autoantibodies-in-patients-with-covid-19\/","title":{"rendered":"Diverse Functional Autoantibodies in Patients with COVID-19"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Elevated levels of autoantibodies (AAbs) targeting extracellular and secreted proteins that modulate immune response were detected in a cohort of COVID-19 patients (n=194) but not in uninfected controls (n=30). <\/span><i><span style=\"font-weight: 400\">In vitro<\/span><\/i><span style=\"font-weight: 400\"> analysis of the plasma concentrations of these targeted proteins indicate altered immunoreceptor signaling and peripheral immune cell composition, suggesting that the AAbs can impair immune function and virologic control. <\/span><i><span style=\"font-weight: 400\">In vivo<\/span><\/i><span style=\"font-weight: 400\"> experiments with mice infected with SARS-CoV-2 demonstrated that the AAbs can exacerbate disease severity.<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Wang et al.\u00a0(May 19, 2021). Diverse Functional Autoantibodies in Patients with COVID-19. Nature. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03631-y\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1038\/s41586-021-03631-y<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Elevated levels of autoantibodies (AAbs) targeting extracellular and secreted proteins that modulate immune response were detected in a cohort of COVID-19 patients (n=194) but not in uninfected controls (n=30). In vitro analysis of the plasma concentrations of these targeted proteins indicate altered immunoreceptor signaling and peripheral immune cell composition, suggesting that the AAbs can impair&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/20\/diverse-functional-autoantibodies-in-patients-with-covid-19\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[32],"topic":[31],"class_list":["post-9927","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-immunity","topic-vaccines-and-immunity"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9927","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9927"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9927\/revisions"}],"predecessor-version":[{"id":9928,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9927\/revisions\/9928"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9927"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9927"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9927"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9927"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}