{"id":9973,"date":"2021-05-24T11:44:13","date_gmt":"2021-05-24T18:44:13","guid":{"rendered":"https:\/\/depts.washington.edu\/pandemicalliance\/?p=9973"},"modified":"2021-05-25T11:45:00","modified_gmt":"2021-05-25T18:45:00","slug":"sars-cov-2-b-1-1-7-and-b-1-351-spike-variants-bind-human-ace2-with-increased-affinity","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/24\/sars-cov-2-b-1-1-7-and-b-1-351-spike-variants-bind-human-ace2-with-increased-affinity\/","title":{"rendered":"SARS-CoV-2 B.1.1.7 and B.1.351 Spike Variants Bind Human ACE2 with Increased Affinity"},"content":{"rendered":"<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">SARS-CoV-2 B.1.1.7 and B.1.351 variants were found to have 2- and 4.6-times higher binding affinity, respectively, for the human ACE2 receptor than the wildtype virus. The authors suggest that this may explain some of the observed increased transmissibility of these variants.\u00a0\u00a0<\/span><\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Ramanathan et al.\u00a0(May 2021). SARS-CoV-2 B.1.1.7 and B.1.351 Spike Variants Bind Human ACE2 with Increased Affinity. The Lancet Infectious Diseases. <\/span><\/i><a href=\"https:\/\/doi.org\/10.1016\/S1473-3099(21)00262-0\"><span style=\"font-weight: 400\">https:\/\/doi.org\/10.1016\/S1473-3099(21)00262-0<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>SARS-CoV-2 B.1.1.7 and B.1.351 variants were found to have 2- and 4.6-times higher binding affinity, respectively, for the human ACE2 receptor than the wildtype virus. The authors suggest that this may explain some of the observed increased transmissibility of these variants.\u00a0\u00a0 Ramanathan et al.\u00a0(May 2021). SARS-CoV-2 B.1.1.7 and B.1.351 Spike Variants Bind Human ACE2 with&#8230;<\/p>\n<div><a class=\"more\" href=\"https:\/\/depts.washington.edu\/pandemicalliance\/2021\/05\/24\/sars-cov-2-b-1-1-7-and-b-1-351-spike-variants-bind-human-ace2-with-increased-affinity\/\">Read more<\/a><\/div>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[141],"topic":[21],"class_list":["post-9973","post","type-post","status-publish","format-standard","hentry","category-article-summary","tag-variant","topic-transmission"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/comments?post=9973"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9973\/revisions"}],"predecessor-version":[{"id":9974,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/posts\/9973\/revisions\/9974"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/media?parent=9973"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/categories?post=9973"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/tags?post=9973"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/depts.washington.edu\/pandemicalliance\/wp-json\/wp\/v2\/topic?post=9973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}