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Herbal supplements and pregnancy

Herbal supplements are used during pregnancy for a variety of reasons; some are safe, others can be harmful. The majority of herbal remedies have not been studied, and their effects during pregnancy are unknown. Herbal supplement use during lactation is covered briefly in Module 8, Breastfeeding Assessment and Support.

Product Purported Use Comments (Including safety, efficacy, evidence)
Black Cohosh

Uterine stimulant

Labor-inducing aid

Efficacy is unclear

Caution during pregnancy (especially during the first trimester) because of potential (though unproven) labor-inducing properties

Caution during lactation is suggested, due to potential hormonal effects

Blue cohosh (not black) is also used for gynecologic disorders and has a greater potential for toxicity than black cohosh.

Echinacea Anti-infective agent, remedy for viral infections (especially upper respiratory infections)

Evidence for use in treating upper respiratory infections is strong

Oral consumption during the first trimester was not associated with an increased risk of major malformations

Caution for use during lactation until stronger evidence about safety is available

Consider potential for interactions between echinacea and other medications

Ginger Treatment of hyperemesis

250 mg powdered capsules

The American College Obstetricians and Gynecologists Practice Pattern suggests this as option (ACOG, 2015)

Some controversy over safety of high doses, 1.0-1.5 g doses have been shown effective in some RCTs (in vitro studies of specific, isolated constituents indicated mutagenicity; not borne out in clinical trials) (Low Dog, 2009)

Ginkgo

Memory boosting

Treatment for asthma, sexual disfunction, hormonal changes

Major safety concern with use during pregnancy is anti-platelet activity and prolonged bleeding during delivery

Some case reports of adverse effects during pregnancy related to product adulteration; clinicians should be aware of manufacturers who use Good Manufacturing Practices (GMP)

Theoretical evidence for avoiding raw ginkgo seed during pregnancy and lactation

Consider potential for interactions between gingko and other medications

St. John’s Wort

Enhance uterine tone

Treatment for depression

Caution is warranted related to use during pregnancy; safety studies are weak
Potential side effects during lactation include colic, drowsiness, lethargy

Consider potential for serious interactions between St. John's Wort and other medications

References:

Smeriglio A, Tomaino A, Trombetta A. Herbal Products in Pregnancy: Experimental Studies and Clinical Reports. Phytotherapy Research. 2014;28(8):1107-1116.

Low Dog T. The use of botanicals during pregnancy and lactation. Alt Ther Health Med. 2009;15(1):54-58.


Table 2-1. Selected herbal supplements and implications during pregnancy

 

Herbs to avoid during pregnancy
Herb Action
Blue cohosh Oxytoxic
Black cohosh Uterine stimulant effects (used by some midwives in preparation for labor)
Chamomile, valerian Antispasmodic, sedative
Goldenseal Oxytoxic
Dong quai Stimulant, relaxant
Comfrey "internal use" Liver toxicity
Ephedra Uterine stimulant
Chaste tree Uterine stimulant
Pharmacologic dose of zinc Premature and stillbirth
Reference: Born D, Barron ML. Herb use in pregnancy: what nurses should know. MCN 2005; 30(3):201-206.

Table 2-2. Herbs to avoid during pregnancy

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Last updated: 02/13/2019