{"id":12,"date":"2015-09-23T22:26:13","date_gmt":"2015-09-23T22:26:13","guid":{"rendered":"http:\/\/depts.washington.edu\/pzlab\/wordpress\/?page_id=12"},"modified":"2017-06-12T02:15:43","modified_gmt":"2017-06-12T02:15:43","slug":"research","status":"publish","type":"page","link":"https:\/\/depts.washington.edu\/pzlab\/wordpress\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<p><strong>Investigation of inorganic nano-structures for\u00a0<\/strong><b>photothermal\u00a0applications<\/b><\/p>\n<p>Significant research effort has been made towards the development of nanoscale materials for targeted cancer hyperthermia. \u00a0This approach relies first on engineering the nanomaterials to bind selectively to cancer tissue by designing the morphology and surface of the material to enhance permeability and uptake. Near-infrared lasers are used to heat the particles to create local thermal damage that hinders angiogenesis and DNA-repair within tumor tissue. Gold nanoparticles have strong near-infrared surface plasmon absorption which leads to substantial heating of subcutaneous tumors. It is possible to superheat aqueous buffers to over 200\u00b0C above the boiling point of water at atmospheric pressure due to extremely large\u00a0<a href=\"http:\/\/en.wikipedia.org\/wiki\/Young%E2%80%93Laplace_equation\">Young-Laplace<\/a>\u00a0surface pressures arising from the interplay between tremendous curvature on surface tension at nanometer length scales. Research in the Pauzauskie lab is focused on the design, synthesis, and experimental characterization of biocompatible nanomaterials for targeted photothermal therapies.<\/p>\n<p>Relevant publications:<\/p>\n<ul>\n<li><strong><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adom.201500143\/abstract\">Photothermal superheating of water with ion-implanted silicon nanowires<\/a><\/strong>. Roder, P.B., Manandhar, S., Smith, B.E., Zhou, X., Shutthanandan, V., Pauzauskie, P.J.\u00a0<strong>(2015)<\/strong>\u00a0<em>Adv. Opt. Mater.<strong>\u00a0<\/strong><\/em>3(10):1362-1367.<\/li>\n<li><strong><a href=\"http:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2015\/nr\/c4nr06164k#!divAbstract\">Nanoscale materials for hyperthermal theranostics<\/a><\/strong>. Smith, B.E., Roder, P.B., Zhou, X.Z., Pauzauskie, P.J.\u00a0<strong>(2015)\u00a0<\/strong><em>Nanoscale<\/em>\u00a07:7115-7126.<\/li>\n<li><strong><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jp4078745\">Photothermal Heating of Nanowires<\/a><\/strong>.\u00a0Roder, P.B., Smith, B.E., Davis, E.J., Pauzauskie, P.J.\u00a0<strong>(2014)<\/strong>\u00a0<em>J. Phys. Chem. C<\/em>, 118:1407-1416<strong>.<\/strong><\/li>\n<li><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/la303250e\"><strong>Nanowire heating by optical electromagnetic irradiation<\/strong>.<\/a>\u00a0Roder, P.B., Pauzauskie, P.J., Davis, E.J.\u00a0<strong>(2012)\u00a0<\/strong><em>Langmuir<\/em>\u00a028:16177-16185.<\/li>\n<\/ul>\n<hr \/>\n<h2>Featured Video<\/h2>\n<p><iframe width=\"700\" height=\"394\" src=\"https:\/\/www.youtube.com\/embed\/dh4Qf3qpPSg?feature=oembed\" frameborder=\"0\" allowfullscreen><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigation of inorganic nano-structures for\u00a0photothermal\u00a0applications Significant research effort has been made towards the development of nanoscale materials for targeted cancer hyperthermia. \u00a0This approach relies first on engineering the nanomaterials to bind selectively to cancer tissue by designing the morphology and&#8230; <a class=\"read-more-button\" href=\"https:\/\/depts.washington.edu\/pzlab\/wordpress\/research\/\">Read more &gt;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_eb_attr":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/pzlab\/wordpress\/wp-json\/wp\/v2\/pages\/12"}],"collection":[{"href":"https:\/\/depts.washington.edu\/pzlab\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/depts.washington.edu\/pzlab\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pzlab\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/pzlab\/wordpress\/wp-json\/wp\/v2\/comments?post=12"}],"version-history":[{"count":3,"href":"https:\/\/depts.washington.edu\/pzlab\/wordpress\/wp-json\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":310,"href":"https:\/\/depts.washington.edu\/pzlab\/wordpress\/wp-json\/wp\/v2\/pages\/12\/revisions\/310"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/pzlab\/wordpress\/wp-json\/wp\/v2\/media?parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}