{"id":1042,"date":"2017-10-05T21:22:17","date_gmt":"2017-10-05T21:22:17","guid":{"rendered":"http:\/\/depts.washington.edu\/rablab\/?p=1042"},"modified":"2017-10-05T21:22:50","modified_gmt":"2017-10-05T21:22:50","slug":"missense-mutations-neurodevelopmental","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/rablab\/2017\/10\/05\/missense-mutations-neurodevelopmental\/","title":{"rendered":"Missense Mutations identify neurodevelopmental disorder genes"},"content":{"rendered":"<p>A recent publication from Dr. Evan Eichler, Dr. Raphe Bernier and others discuss how missense mutations may identify neurodevelopmental disorders such as Autism.\u00a0 \u00a0A missense mutation is when a single\u00a0DNA letter\u00a0is swapped with another, altering one amino acid in a protein.\u00a0 Although many missense mutations are harmless,\u00a0Eichler, Bernier and others have identified some potentially harmful missense mutations associated with neurodevelopmental disorders. The research was pusblished\u00a0in 2017 in <a href=\"http:\/\/www.nature.com\/neuro\/journal\/v20\/n8\/full\/nn.4589.html?foxtrotcallback=true\">Nature Neuroscience<\/a>.\u00a0\u00a0Spectrum News also discusses the study results with interviews from Dr. Eichler and others involved.<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"eo0WX4fCRe\"><p><a href=\"https:\/\/www.spectrumnews.org\/news\/scan-missense-mutations-marks-new-suspects-autism-risk\/\">Scan of &lsquo;missense\u2019 mutations marks new suspects for autism risk<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Scan of &lsquo;missense\u2019 mutations marks new suspects for autism risk&#8221; &#8212; Spectrum | Autism Research News\" src=\"https:\/\/www.spectrumnews.org\/news\/scan-missense-mutations-marks-new-suspects-autism-risk\/embed\/#?secret=7zpSCFLc3D#?secret=eo0WX4fCRe\" data-secret=\"eo0WX4fCRe\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent publication from Dr. Evan Eichler, Dr. Raphe Bernier and others discuss how missense mutations may identify neurodevelopmental disorders such as Autism.\u00a0 \u00a0A missense mutation is when a single\u00a0DNA letter\u00a0is swapped with another, altering one amino acid in a protein.\u00a0 Although many missense mutations are harmless,\u00a0Eichler, Bernier and others have identified some potentially harmful &hellip; <a href=\"https:\/\/depts.washington.edu\/rablab\/2017\/10\/05\/missense-mutations-neurodevelopmental\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Missense Mutations identify neurodevelopmental disorder genes<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25,13,16],"tags":[],"class_list":["post-1042","post","type-post","status-publish","format-standard","hentry","category-genetics","category-news","category-research"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/rablab\/wp-json\/wp\/v2\/posts\/1042","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/rablab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/rablab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/rablab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/rablab\/wp-json\/wp\/v2\/comments?post=1042"}],"version-history":[{"count":2,"href":"https:\/\/depts.washington.edu\/rablab\/wp-json\/wp\/v2\/posts\/1042\/revisions"}],"predecessor-version":[{"id":1110,"href":"https:\/\/depts.washington.edu\/rablab\/wp-json\/wp\/v2\/posts\/1042\/revisions\/1110"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/rablab\/wp-json\/wp\/v2\/media?parent=1042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/rablab\/wp-json\/wp\/v2\/categories?post=1042"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/rablab\/wp-json\/wp\/v2\/tags?post=1042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}