Rieke Lab
Publications
2017 |
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Jorstad, Nikolas L; Wilken, Matthew S; Grimes, William N; Wohl, Stefanie G; VandenBosch, Leah S; Yoshimatsu, Takeshi; Wong, Rachel O; Rieke, Fred; Reh, Thomas A Stimulation of functional neuronal regeneration from Müller glia in adult mice Journal Article Nature, 548 (7665), pp. 103-107, 2017, ISSN: 0028-0836, (Letter). @article{Jorstad2017b,
title = {Stimulation of functional neuronal regeneration from Müller glia in adult mice}, author = {Nikolas L Jorstad and Matthew S Wilken and William N Grimes and Stefanie G Wohl and Leah S VandenBosch and Takeshi Yoshimatsu and Rachel O Wong and Fred Rieke and Thomas A Reh}, url = {http://dx.doi.org/10.1038/nature23283}, issn = {0028-0836}, year = {2017}, date = {2017-08-03}, journal = {Nature}, volume = {548}, number = {7665}, pages = {103-107}, publisher = {Macmillan Publishers Limited, part of Springer Nature. All rights reserved.}, note = {Letter}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Grimes, William; Songco-aguas, Adree; Rieke, Fred Exploring the neural mechanisms of perceptual rod-cone flicker cancellation Journal Article Investigative Ophthalmology & Visual Science, 58 (8), pp. 2033-2033, 2017, ISSN: 1552-5783. @article{Grimes2017,
title = {Exploring the neural mechanisms of perceptual rod-cone flicker cancellation}, author = {William Grimes and Adree Songco-aguas and Fred Rieke}, url = {http://iovs.arvojournals.org/article.aspx?articleid=2637848}, issn = {1552-5783}, year = {2017}, date = {2017-06-23}, journal = {Investigative Ophthalmology & Visual Science}, volume = {58}, number = {8}, pages = {2033-2033}, abstract = {Abstract Purpose : The overarching goal of this research is to understand how the retina behaves under intermediate lighting conditions (e.g. dawn and dusk) when both rods and cones are active, and to relate the circuit-level retinal processing of rod and cone signals to human perception.Previous human perceptual experiments have revealed interactions between flickering rod and cone stimuli that are thought to occur in the retina. Here we explore the neural basis of rod-cone flicker interference in On and Off ganglion cells that project to the primate magnocellular visual pathways. Methods : Electrophysiology Spike recordings were taken from On and Off parasol retinal ganglion cells in an in vitro non-human primate retina preparation. Light from long and short wavelength LEDs was projected onto the isolated retina to preferentially activate L-cones and rods, respectively. The temporally-modulated, spatially-uniform stimulus was 2textdegree on the retinal surface.Psychophysics After a dark adaptation period, human subjects focused on a small fixation cross while a spot of light (2textdegree) flickered at 10textdegree eccentricity. After each stimulus presentation (2 s) subjects were asked if they detected flicker. Answers were entered into a keyboard and the stimulus was adjusted accordingly until a perceptual flicker threshold was achieved. Similar to electrophysiology experiments, light from the red and blue monitor phosphors were used to to preferentially activate L-cones and rods, respectively. Results : Recordings from On and Off parasol ganglion cells revealed suppressive interactions when long and short wavelength LEDs were co-modulated at 8 Hz. Suppressive interactions became additive when a phase delay of 180textdegree was introduced to one of the two stimuli or when the stimulus frequency was reduced to <6 Hz. Similarly, human subjects reported a boost in flicker threshold when stimuli were co-modulated at 8 Hz, but not at 4 Hz. Introduction of a 180textdegree phase delay between the stimuli produced a dramatic reduction in flicker threshold at 8 Hz. Conclusions : This destructive interference between rod and cone signals appears to reflect a linear combination of kinetically-distinct rod and cone signals upstream of the ganglion cell synaptic inputs. Using our experimental data as a foundation, we construct a mathematical model that captures known rod-cone interactions and accurately predicts retinal output in response to arbitrary time-varying rod and cone stimuli. This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Abstract Purpose : The overarching goal of this research is to understand how the retina behaves under intermediate lighting conditions (e.g. dawn and dusk) when both rods and cones are active, and to relate the circuit-level retinal processing of rod and cone signals to human perception.Previous human perceptual experiments have revealed interactions between flickering rod and cone stimuli that are thought to occur in the retina. Here we explore the neural basis of rod-cone flicker interference in On and Off ganglion cells that project to the primate magnocellular visual pathways. Methods : Electrophysiology Spike recordings were taken from On and Off parasol retinal ganglion cells in an in vitro non-human primate retina preparation. Light from long and short wavelength LEDs was projected onto the isolated retina to preferentially activate L-cones and rods, respectively. The temporally-modulated, spatially-uniform stimulus was 2textdegree on the retinal surface.Psychophysics After a dark adaptation period, human subjects focused on a small fixation cross while a spot of light (2textdegree) flickered at 10textdegree eccentricity. After each stimulus presentation (2 s) subjects were asked if they detected flicker. Answers were entered into a keyboard and the stimulus was adjusted accordingly until a perceptual flicker threshold was achieved. Similar to electrophysiology experiments, light from the red and blue monitor phosphors were used to to preferentially activate L-cones and rods, respectively. Results : Recordings from On and Off parasol ganglion cells revealed suppressive interactions when long and short wavelength LEDs were co-modulated at 8 Hz. Suppressive interactions became additive when a phase delay of 180textdegree was introduced to one of the two stimuli or when the stimulus frequency was reduced to <6 Hz. Similarly, human subjects reported a boost in flicker threshold when stimuli were co-modulated at 8 Hz, but not at 4 Hz. Introduction of a 180textdegree phase delay between the stimuli produced a dramatic reduction in flicker threshold at 8 Hz. Conclusions : This destructive interference between rod and cone signals appears to reflect a linear combination of kinetically-distinct rod and cone signals upstream of the ganglion cell synaptic inputs. Using our experimental data as a foundation, we construct a mathematical model that captures known rod-cone interactions and accurately predicts retinal output in response to arbitrary time-varying rod and cone stimuli. This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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Brinkman, Braden AW; Rieke, Fred; Shea-Brown, Eric; Buice, Michael Effective synaptic interactions in subsampled nonlinear networks with strong coupling Journal Article arXiv preprint arXiv:1702.00865, 2017. @article{brinkman2017effective,
title = {Effective synaptic interactions in subsampled nonlinear networks with strong coupling}, author = { Braden AW Brinkman and Fred Rieke and Eric Shea-Brown and Michael Buice}, url = {https://arxiv.org/abs/1702.00865}, year = {2017}, date = {2017-02-02}, journal = {arXiv preprint arXiv:1702.00865}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Sinha, Raunak; Hoon, Mrinalini; Baudin, Jacob; Okawa, Haruhisa; Wong, Rachel O L; Rieke, Fred Cellular and Circuit Mechanisms Shaping the Perceptual Properties of the Primate Fovea Journal Article Cell, 168 (3), pp. 413 - 426.e12, 2017, ISSN: 0092-8674. @article{SINHA2017413,
title = {Cellular and Circuit Mechanisms Shaping the Perceptual Properties of the Primate Fovea}, author = {Raunak Sinha and Mrinalini Hoon and Jacob Baudin and Haruhisa Okawa and Rachel O L Wong and Fred Rieke}, url = {http://www.sciencedirect.com/science/article/pii/S0092867417300533}, doi = {10.1016/j.cell.2017.01.005}, issn = {0092-8674}, year = {2017}, date = {2017-01-01}, journal = {Cell}, volume = {168}, number = {3}, pages = {413 - 426.e12}, abstract = {The fovea is a specialized region of the retina that dominates the visual perception of primates by providing high chromatic and spatial acuity. While the foveal and peripheral retina share a similar core circuit architecture, they exhibit profound functional differences whose mechanisms are unknown. Using intracellular recordings and structure-function analyses, we examined the cellular and synaptic underpinnings of the primate fovea. Compared to peripheral vision, the fovea displays decreased sensitivity to rapid variations in light inputs; this difference is reflected in the responses of ganglion cells, the output cells of the retina. Surprisingly, and unlike in the periphery, synaptic inhibition minimally shaped the responses of foveal midget ganglion cells. This difference in inhibition cannot however, explain the differences in the temporal sensitivity of foveal and peripheral midget ganglion cells. Instead, foveal cone photoreceptors themselves exhibited slower light responses than peripheral cones, unexpectedly linking cone signals to perceptual sensitivity.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The fovea is a specialized region of the retina that dominates the visual perception of primates by providing high chromatic and spatial acuity. While the foveal and peripheral retina share a similar core circuit architecture, they exhibit profound functional differences whose mechanisms are unknown. Using intracellular recordings and structure-function analyses, we examined the cellular and synaptic underpinnings of the primate fovea. Compared to peripheral vision, the fovea displays decreased sensitivity to rapid variations in light inputs; this difference is reflected in the responses of ganglion cells, the output cells of the retina. Surprisingly, and unlike in the periphery, synaptic inhibition minimally shaped the responses of foveal midget ganglion cells. This difference in inhibition cannot however, explain the differences in the temporal sensitivity of foveal and peripheral midget ganglion cells. Instead, foveal cone photoreceptors themselves exhibited slower light responses than peripheral cones, unexpectedly linking cone signals to perceptual sensitivity.
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2016 |
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Rudd, Michael E; Rieke, Fred Brightness in human rod vision depends on slow neural adaptation to quantum statistics of light Journal Article Journal of Vision, 16 (14), pp. 23, 2016. @article{doi:10.1167/16.14.23,
title = {Brightness in human rod vision depends on slow neural adaptation to quantum statistics of light}, author = {Michael E Rudd and Fred Rieke}, url = {http://jov.arvojournals.org/article.aspx?articleid=2589484}, doi = {10.1167/16.14.23}, year = {2016}, date = {2016-11-01}, journal = {Journal of Vision}, volume = {16}, number = {14}, pages = {23}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Sinha, Raunak; Lee, Amy; Rieke, Fred; Haeseleer, Francoise Lack of CaBP1/caldendrin or CaBP2 leads to altered ganglion cell responses Journal Article eNeuro, 2016. @article{SinhaENEURO.0099-16.2016,
title = {Lack of CaBP1/caldendrin or CaBP2 leads to altered ganglion cell responses}, author = {Raunak Sinha and Amy Lee and Fred Rieke and Francoise Haeseleer}, url = {http://www.eneuro.org/content/early/2016/10/20/ENEURO.0099-16.2016}, doi = {10.1523/ENEURO.0099-16.2016}, year = {2016}, date = {2016-10-20}, journal = {eNeuro}, publisher = {Society for Neuroscience}, abstract = {Calcium-binding proteins (CaBPs) form a subfamily of calmodulin-like proteins that were cloned from the retina. CaBP4 and CaBP5 have been shown to be important for normal visual function.Although CaBP1/caldendrin and CaBP2 have been shown to modulate various targets in vitro, it is not known if they contribute to the transmission of light responses through the retina. Therefore, we generated mice that lack CaBP2 or CaBP1/caldendrin (Cabp2-/- and Cabp1-/-) to test if these CaBPs are essential for normal retinal function. By immunohistochemistry, the overall morphology of Cabp1-/- and Cabp2-/- retinas and the number of synaptic ribbons appear normal; transmission electron microscopy shows normal tethered ribbon synapses and synaptic vesicles as in wild-type retina. However, whole-cell patch clamp recordings showed that light responses of retinal ganglion cells of Cabp2-/- and Cabp1 -/- mice differ in amplitude and kinetics from those of wild-type mice. We conclude that CaBP1/caldendrin and CaBP2 are not required for normal gross retinal and synapse morphology but are necessary for the proper transmission of light responses through the retina; like other CaBPs, CaBP1/caldendrin and CaBP2 likely act by modulating presynaptic Ca2+-dependent signaling mechanisms.Significance Statement: Electrical signals generated by the photoreceptors in response to incident light are processed by diverse retinal neurons before being sent to the brain. Ca2+ signaling controls both cellular and synaptic mechanisms that shape signals as they are transmitted through the retina. Ca2+-binding proteins, including the calmodulin-like CaBPs, exert Ca2+-dependent effects on specific target proteins—e.g. ion channels. To determine whether CaBP1/caldendrin and CaBP2 are important for normal retinal function, we took advantage of CaBP1/caldendrin and CaBP2 deficient mice. Although these proteins are not required for retinal development and maintenance, CaBP1/caldendrin and CaBP2 are important for normal transfer of light signals through the retina.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Calcium-binding proteins (CaBPs) form a subfamily of calmodulin-like proteins that were cloned from the retina. CaBP4 and CaBP5 have been shown to be important for normal visual function.Although CaBP1/caldendrin and CaBP2 have been shown to modulate various targets in vitro, it is not known if they contribute to the transmission of light responses through the retina. Therefore, we generated mice that lack CaBP2 or CaBP1/caldendrin (Cabp2-/- and Cabp1-/-) to test if these CaBPs are essential for normal retinal function. By immunohistochemistry, the overall morphology of Cabp1-/- and Cabp2-/- retinas and the number of synaptic ribbons appear normal; transmission electron microscopy shows normal tethered ribbon synapses and synaptic vesicles as in wild-type retina. However, whole-cell patch clamp recordings showed that light responses of retinal ganglion cells of Cabp2-/- and Cabp1 -/- mice differ in amplitude and kinetics from those of wild-type mice. We conclude that CaBP1/caldendrin and CaBP2 are not required for normal gross retinal and synapse morphology but are necessary for the proper transmission of light responses through the retina; like other CaBPs, CaBP1/caldendrin and CaBP2 likely act by modulating presynaptic Ca2+-dependent signaling mechanisms.Significance Statement: Electrical signals generated by the photoreceptors in response to incident light are processed by diverse retinal neurons before being sent to the brain. Ca2+ signaling controls both cellular and synaptic mechanisms that shape signals as they are transmitted through the retina. Ca2+-binding proteins, including the calmodulin-like CaBPs, exert Ca2+-dependent effects on specific target proteins—e.g. ion channels. To determine whether CaBP1/caldendrin and CaBP2 are important for normal retinal function, we took advantage of CaBP1/caldendrin and CaBP2 deficient mice. Although these proteins are not required for retinal development and maintenance, CaBP1/caldendrin and CaBP2 are important for normal transfer of light signals through the retina.
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Brinkman, Braden A W; Weber, Alison I; Rieke, Fred; Shea-Brown, Eric How Do Efficient Coding Strategies Depend on Origins of Noise in Neural Circuits? Journal Article PLOS Computational Biology, 12 (10), pp. e1005150, 2016. @article{Brinkman2016,
title = {How Do Efficient Coding Strategies Depend on Origins of Noise in Neural Circuits?}, author = {Braden A W Brinkman and Alison I Weber and Fred Rieke and Eric Shea-Brown}, url = {https://doi.org/10.1371/journal.pcbi.1005150}, doi = {10.1371/journal.pcbi.1005150}, year = {2016}, date = {2016-10-14}, journal = {PLOS Computational Biology}, volume = {12}, number = {10}, pages = {e1005150}, publisher = {Public Library of Science}, abstract = {Author Summary For decades the efficient coding hypothesis has been a guiding principle in determining how neural systems can most efficiently represent their inputs. However, conclusions about whether neural circuits are performing optimally depend on assumptions about the noise sources encountered by neural signals as they are transmitted. Here, we provide a coherent picture of how optimal encoding strategies depend on noise strength, type, location, and correlations. Our results reveal that nonlinearities that are efficient if noise enters the circuit in one location may be inefficient if noise actually enters in a different location. This offers new explanations for why different sensory circuits, or even a given circuit under different environmental conditions, might have different encoding properties.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Author Summary For decades the efficient coding hypothesis has been a guiding principle in determining how neural systems can most efficiently represent their inputs. However, conclusions about whether neural circuits are performing optimally depend on assumptions about the noise sources encountered by neural signals as they are transmitted. Here, we provide a coherent picture of how optimal encoding strategies depend on noise strength, type, location, and correlations. Our results reveal that nonlinearities that are efficient if noise enters the circuit in one location may be inefficient if noise actually enters in a different location. This offers new explanations for why different sensory circuits, or even a given circuit under different environmental conditions, might have different encoding properties.
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Sinha, Raunak; Hoon, Mrinalini; Wong, Rachel O; Rieke, Fred Role of GABAA-receptor mediated presynaptic inhibition in shaping ON ganglion cell responses Journal Article Investigative Ophthalmology & Visual Science, 57 (12), 2016. @article{sinha2016roleb,
title = {Role of GABAA-receptor mediated presynaptic inhibition in shaping ON ganglion cell responses}, author = {Raunak Sinha and Mrinalini Hoon and Rachel O Wong and Fred Rieke}, year = {2016}, date = {2016-09-26}, journal = {Investigative Ophthalmology & Visual Science}, volume = {57}, number = {12}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Kuo, Sidney P; Okawa, Haruhisa; Pacholec, Justin; Wong, Rachel O; Rieke, Fred Divergence of visual signals in parallel ON cone bipolar cell pathways of the mouse retina Journal Article Investigative Ophthalmology & Visual Science, 57 (12), pp. 593-593, 2016, ISSN: 1552-5783. @article{Kuo2016,
title = {Divergence of visual signals in parallel ON cone bipolar cell pathways of the mouse retina}, author = {Sidney P Kuo and Haruhisa Okawa and Justin Pacholec and Rachel O Wong and Fred Rieke}, url = {http://iovs.arvojournals.org/article.aspx?articleid=2559403}, issn = {1552-5783}, year = {2016}, date = {2016-09-26}, journal = {Investigative Ophthalmology & Visual Science}, volume = {57}, number = {12}, pages = {593-593}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Haeseleer, Francoise J; Sinha, Raunak; Lee, Amy; Rieke, Fred Characterization of CaBP1/caldendrin and CaBP2 knockout mice retina Journal Article Investigative Ophthalmology & Visual Science, 57 (12), pp. 2761-2761, 2016, ISSN: 1552-5783. @article{Haeseleer2016,
title = {Characterization of CaBP1/caldendrin and CaBP2 knockout mice retina}, author = {Francoise J Haeseleer and Raunak Sinha and Amy Lee and Fred Rieke}, url = {http://iovs.arvojournals.org/article.aspx?articleid=2561147}, issn = {1552-5783}, year = {2016}, date = {2016-09-26}, journal = {Investigative Ophthalmology & Visual Science}, volume = {57}, number = {12}, pages = {2761-2761}, abstract = {Abstract Purpose : Calcium-binding proteins (CaBPs) form a subfamily of calmodulin-like proteins that were cloned from the retina. CaBP4 and CaBP5 have been shown to be important for normal visual function. Although CaBP1 and CaBP2 have been shown to modulate various targets in vitro, the physiological roles of CaBP1 and CaBP2 in vivo has not yet been investigated. The goal of this study is to characterize the retinal morphology and function of CaBP1/caldendrin and CaBP2 knockout (KO) mice. Methods : CaBP2 KO mice were generated by homologous recombination in ES cells. CaBP1/caldendrin KO mice were generated previously. The absence of CaBP1/caldendrin and CaBP2 in CaBP1/caldendrin KO and CaBP2 KO mice, respectively, was investigated using RT-PCR and immunohistochemistry. The retinal morphology and visual function of six-week-old CaBP1/caldendrin KO and CaBP2 KO mice were analyzed by confocal and electron microscopy and by whole-cell patch-clamp recordings of alpha-like retinal ganglion cells. Results : CaBP2 KO mice were viable and did not show any apparent physiological deficits or breeding problems. No evidence of morphological retinal changes were observed in CaBP1/caldendrin KO and CaBP2 KO mice compared with wild-type mice. However, whole-cell patch clamp recordings of the light responses of alpha-like retinal ganglion cells showed that these light responses in CaBP1/caldendrin KO and CaBP2 KO mice were altered compared with those of wild-type mice. Conclusions : Our results show that lack of CaBP1/caldendrin or CaBP2 results in altered light responses of alpha-like retinal ganglion cells, indicating an essential role for CaBP1/caldendrin and CaBP2 for the normal transmission of light signals throughout the retinal circuitry. This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Abstract Purpose : Calcium-binding proteins (CaBPs) form a subfamily of calmodulin-like proteins that were cloned from the retina. CaBP4 and CaBP5 have been shown to be important for normal visual function. Although CaBP1 and CaBP2 have been shown to modulate various targets in vitro, the physiological roles of CaBP1 and CaBP2 in vivo has not yet been investigated. The goal of this study is to characterize the retinal morphology and function of CaBP1/caldendrin and CaBP2 knockout (KO) mice. Methods : CaBP2 KO mice were generated by homologous recombination in ES cells. CaBP1/caldendrin KO mice were generated previously. The absence of CaBP1/caldendrin and CaBP2 in CaBP1/caldendrin KO and CaBP2 KO mice, respectively, was investigated using RT-PCR and immunohistochemistry. The retinal morphology and visual function of six-week-old CaBP1/caldendrin KO and CaBP2 KO mice were analyzed by confocal and electron microscopy and by whole-cell patch-clamp recordings of alpha-like retinal ganglion cells. Results : CaBP2 KO mice were viable and did not show any apparent physiological deficits or breeding problems. No evidence of morphological retinal changes were observed in CaBP1/caldendrin KO and CaBP2 KO mice compared with wild-type mice. However, whole-cell patch clamp recordings of the light responses of alpha-like retinal ganglion cells showed that these light responses in CaBP1/caldendrin KO and CaBP2 KO mice were altered compared with those of wild-type mice. Conclusions : Our results show that lack of CaBP1/caldendrin or CaBP2 results in altered light responses of alpha-like retinal ganglion cells, indicating an essential role for CaBP1/caldendrin and CaBP2 for the normal transmission of light signals throughout the retinal circuitry. This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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Della Santina, Luca; Kuo, Sidney P.; Yoshimatsu, Takeshi; Okawa, Haruhisa; Suzuki, Sachihiro C.; Hoon, Mrinalini; Tsuboyama, Kotaro; Rieke, Fred; Wong, Rachel O.L. Glutamatergic Monopolar Interneurons Provide a Novel Pathway of Excitation in the Mouse Retina Journal Article Current Biology, 26 (15), pp. 2070 - 2077, 2016, ISSN: 0960-9822. @article{DELLASANTINA20162070,
title = {Glutamatergic Monopolar Interneurons Provide a Novel Pathway of Excitation in the Mouse Retina}, author = {Luca Della Santina and Sidney P. Kuo and Takeshi Yoshimatsu and Haruhisa Okawa and Sachihiro C. Suzuki and Mrinalini Hoon and Kotaro Tsuboyama and Fred Rieke and Rachel O.L. Wong}, url = {http://www.sciencedirect.com/science/article/pii/S0960982216306558}, doi = {http://dx.doi.org/10.1016/j.cub.2016.06.016}, issn = {0960-9822}, year = {2016}, date = {2016-08-08}, journal = {Current Biology}, volume = {26}, number = {15}, pages = {2070 - 2077}, abstract = {Excitatory and inhibitory neurons in the CNS are distinguished by several features, including morphology, transmitter content, and synapse architecture [1]. Such distinctions are exemplified in the vertebrate retina. Retinal bipolar cells are polarized glutamatergic neurons receiving direct photoreceptor input, whereas amacrine cells are usually monopolar inhibitory interneurons with synapses almost exclusively in the inner retina [2]. Bipolar but not amacrine cell synapses have presynaptic ribbon-like structures at their transmitter release sites. We identified a monopolar interneuron in the mouse retina that resembles amacrine cells morphologically but is glutamatergic and, unexpectedly, makes ribbon synapses. These glutamatergic monopolar interneurons (GluMIs) do not receive direct photoreceptor input, and their light responses are strongly shaped by both ON and OFF pathway-derived inhibitory input. GluMIs contact and make almost as many synapses as type 2 OFF bipolar cells onto OFF-sustained A-type (AOFF-S) retinal ganglion cells (RGCs). However, GluMIs and type 2 OFF bipolar cells possess functionally distinct light-driven responses and may therefore mediate separate components of the excitatory synaptic input to AOFF-S RGCs. The identification of GluMIs thus unveils a novel cellular component of excitatory circuits in the vertebrate retina, underscoring the complexity in defining cell types even in this well-characterized region of the CNS.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Excitatory and inhibitory neurons in the CNS are distinguished by several features, including morphology, transmitter content, and synapse architecture [1]. Such distinctions are exemplified in the vertebrate retina. Retinal bipolar cells are polarized glutamatergic neurons receiving direct photoreceptor input, whereas amacrine cells are usually monopolar inhibitory interneurons with synapses almost exclusively in the inner retina [2]. Bipolar but not amacrine cell synapses have presynaptic ribbon-like structures at their transmitter release sites. We identified a monopolar interneuron in the mouse retina that resembles amacrine cells morphologically but is glutamatergic and, unexpectedly, makes ribbon synapses. These glutamatergic monopolar interneurons (GluMIs) do not receive direct photoreceptor input, and their light responses are strongly shaped by both ON and OFF pathway-derived inhibitory input. GluMIs contact and make almost as many synapses as type 2 OFF bipolar cells onto OFF-sustained A-type (AOFF-S) retinal ganglion cells (RGCs). However, GluMIs and type 2 OFF bipolar cells possess functionally distinct light-driven responses and may therefore mediate separate components of the excitatory synaptic input to AOFF-S RGCs. The identification of GluMIs thus unveils a novel cellular component of excitatory circuits in the vertebrate retina, underscoring the complexity in defining cell types even in this well-characterized region of the CNS.
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Turner, Maxwell H.; Rieke, Fred Synaptic Rectification Controls Nonlinear Spatial Integration of Natural Visual Inputs Journal Article Neuron, 90 (6), pp. 1257 - 1271, 2016, ISSN: 0896-6273. @article{TURNER20161257,
title = {Synaptic Rectification Controls Nonlinear Spatial Integration of Natural Visual Inputs}, author = {Maxwell H. Turner and Fred Rieke}, url = {http://www.sciencedirect.com/science/article/pii/S0896627316301660}, doi = {10.1016/j.neuron.2016.05.006}, issn = {0896-6273}, year = {2016}, date = {2016-06-15}, journal = {Neuron}, volume = {90}, number = {6}, pages = {1257 - 1271}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Kuo, Sidney P.; Schwartz, Gregory W.; Rieke, Fred Nonlinear Spatiotemporal Integration by Electrical and Chemical Synapses in the Retina Journal Article Neuron, 90 (2), pp. 320 - 332, 2016, ISSN: 0896-6273. @article{KUO2016320,
title = {Nonlinear Spatiotemporal Integration by Electrical and Chemical Synapses in the Retina}, author = {Sidney P. Kuo and Gregory W. Schwartz and Fred Rieke}, url = {http://www.sciencedirect.com/science/article/pii/S0896627316002129}, doi = {http://dx.doi.org/10.1016/j.neuron.2016.03.012}, issn = {0896-6273}, year = {2016}, date = {2016-04-20}, journal = {Neuron}, volume = {90}, number = {2}, pages = {320 - 332}, abstract = {Electrical and chemical synapses coexist in circuits throughout the CNS. Yet, it is not well understood how electrical and chemical synaptic transmission interact to determine the functional output of networks endowed with both types of synapse. We found that release of glutamate from bipolar cells onto retinal ganglion cells (RGCs) was strongly shaped by gap-junction-mediated electrical coupling within the bipolar cell network of the mouse retina. Specifically, electrical synapses spread signals laterally between bipolar cells, and this lateral spread contributed to a nonlinear enhancement of bipolar cell output to visual stimuli presented closely in space and time. Our findings thus (1) highlight how electrical and chemical transmission can work in concert to influence network output and (2) reveal a previously unappreciated circuit mechanism that increases RGC sensitivity to spatiotemporally correlated input, such as that produced by motion.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Electrical and chemical synapses coexist in circuits throughout the CNS. Yet, it is not well understood how electrical and chemical synaptic transmission interact to determine the functional output of networks endowed with both types of synapse. We found that release of glutamate from bipolar cells onto retinal ganglion cells (RGCs) was strongly shaped by gap-junction-mediated electrical coupling within the bipolar cell network of the mouse retina. Specifically, electrical synapses spread signals laterally between bipolar cells, and this lateral spread contributed to a nonlinear enhancement of bipolar cell output to visual stimuli presented closely in space and time. Our findings thus (1) highlight how electrical and chemical transmission can work in concert to influence network output and (2) reveal a previously unappreciated circuit mechanism that increases RGC sensitivity to spatiotemporally correlated input, such as that produced by motion.
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Zylberberg, Joel; Cafaro, Jon; Turner, Maxwell H.; Shea-Brown, Eric; Rieke, Fred Direction-Selective Circuits Shape Noise to Ensure a Precise Population Code Journal Article Neuron, 89 (2), pp. 369 - 383, 2016, ISSN: 0896-6273. @article{ZYLBERBERG2016369,
title = {Direction-Selective Circuits Shape Noise to Ensure a Precise Population Code}, author = {Joel Zylberberg and Jon Cafaro and Maxwell H. Turner and Eric Shea-Brown and Fred Rieke}, url = {http://www.sciencedirect.com/science/article/pii/S0896627315010259}, doi = {http://dx.doi.org/10.1016/j.neuron.2015.11.019}, issn = {0896-6273}, year = {2016}, date = {2016-01-20}, journal = {Neuron}, volume = {89}, number = {2}, pages = {369 - 383}, abstract = {Neural responses are noisy, and circuit structure can correlate this noise across neurons. Theoretical studies show that noise correlations can have diverse effects on population coding, but these studies rarely explore stimulus dependence of noise correlations. Here, we show that noise correlations in responses of ON-OFF direction-selective retinal ganglion cells are strongly stimulus dependent, and we uncover the circuit mechanisms producing this stimulus dependence. A population model based on these mechanistic studies shows that stimulus-dependent noise correlations improve the encoding of motion direction 2-fold compared to independent noise. This work demonstrates a mechanism by which a neural circuit effectively shapes its signal and noise in concert, minimizing corruption of signal by noise. Finally, we generalize our findings beyond direction coding in the retina and show that stimulus-dependent correlations will generally enhance information coding in populations of diversely tuned neurons.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Neural responses are noisy, and circuit structure can correlate this noise across neurons. Theoretical studies show that noise correlations can have diverse effects on population coding, but these studies rarely explore stimulus dependence of noise correlations. Here, we show that noise correlations in responses of ON-OFF direction-selective retinal ganglion cells are strongly stimulus dependent, and we uncover the circuit mechanisms producing this stimulus dependence. A population model based on these mechanistic studies shows that stimulus-dependent noise correlations improve the encoding of motion direction 2-fold compared to independent noise. This work demonstrates a mechanism by which a neural circuit effectively shapes its signal and noise in concert, minimizing corruption of signal by noise. Finally, we generalize our findings beyond direction coding in the retina and show that stimulus-dependent correlations will generally enhance information coding in populations of diversely tuned neurons.
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2015 |
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Zylberberg, Joel; Cafaro, Jon; Turner, Maxwell; Rieke, Fred; Shea-Brown, Eric Limited range correlations, when modulated by firing rate, can substantially improve neural population coding Journal Article BMC Neuroscience, 16 (1), pp. O16, 2015. @article{zylberberg2015limited,
title = {Limited range correlations, when modulated by firing rate, can substantially improve neural population coding}, author = { Joel Zylberberg and Jon Cafaro and Maxwell Turner and Fred Rieke and Eric Shea-Brown}, url = {https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-16-S1-O16}, year = {2015}, date = {2015-12-18}, journal = {BMC Neuroscience}, volume = {16}, number = {1}, pages = {O16}, publisher = {BioMed Central}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Hass, Charles A; Angueyra, Juan M; Lindbloom-Brown, Zachary; Rieke, Fred; Horwitz, Gregory D Chromatic detection from cone photoreceptors to V1 neurons to behavior in rhesus monkeys Journal Article Journal of vision, 15 (15), pp. 1–1, 2015. @article{hass2015chromatic,
title = {Chromatic detection from cone photoreceptors to V1 neurons to behavior in rhesus monkeys}, author = { Charles A Hass and Juan M Angueyra and Zachary Lindbloom-Brown and Fred Rieke and Gregory D Horwitz}, url = {http://jov.arvojournals.org/article.aspx?articleid=2468654}, year = {2015}, date = {2015-11-01}, journal = {Journal of vision}, volume = {15}, number = {15}, pages = {1--1}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Hoon, Mrinalini; Sinha, Raunak; Okawa, Haruhisa; Suzuki, Sachihiro C; Hirano, Arlene A; Brecha, Nicholas; Rieke, Fred; Wong, Rachel OL Neurotransmission plays contrasting roles in the maturation of inhibitory synapses on axons and dendrites of retinal bipolar cells Journal Article Proceedings of the National Academy of Sciences, 112 (41), pp. 12840–12845, 2015. @article{hoon2015neurotransmission,
title = {Neurotransmission plays contrasting roles in the maturation of inhibitory synapses on axons and dendrites of retinal bipolar cells}, author = { Mrinalini Hoon and Raunak Sinha and Haruhisa Okawa and Sachihiro C Suzuki and Arlene A Hirano and Nicholas Brecha and Fred Rieke and Rachel OL Wong}, url = {http://www.pnas.org/content/112/41/12840.short}, year = {2015}, date = {2015-10-13}, journal = {Proceedings of the National Academy of Sciences}, volume = {112}, number = {41}, pages = {12840--12845}, publisher = {National Acad Sciences}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Manookin, Michael B; Puller, Christian; Rieke, Fred; Neitz, Jay; Neitz, Maureen Distinctive receptive field and physiological properties of a wide-field amacrine cell in the macaque monkey retina Journal Article Journal of neurophysiology, 114 (3), pp. 1606–1616, 2015. @article{manookin2015distinctive,
title = {Distinctive receptive field and physiological properties of a wide-field amacrine cell in the macaque monkey retina}, author = { Michael B Manookin and Christian Puller and Fred Rieke and Jay Neitz and Maureen Neitz}, url = {http://jn.physiology.org/content/114/3/1606}, year = {2015}, date = {2015-09-01}, journal = {Journal of neurophysiology}, volume = {114}, number = {3}, pages = {1606--1616}, publisher = {Am Physiological Soc}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Grimes, William N; Zhang, Jun; Tian, Hua; Graydon, Cole W; Hoon, Mrinalini; Rieke, Fred; Diamond, Jeffrey S Complex inhibitory microcircuitry regulates retinal signaling near visual threshold Journal Article Journal of neurophysiology, 114 (1), pp. 341–353, 2015. @article{grimes2015complex,
title = {Complex inhibitory microcircuitry regulates retinal signaling near visual threshold}, author = { William N Grimes and Jun Zhang and Hua Tian and Cole W Graydon and Mrinalini Hoon and Fred Rieke and Jeffrey S Diamond}, url = {http://jn.physiology.org/content/114/1/341}, year = {2015}, date = {2015-07-01}, journal = {Journal of neurophysiology}, volume = {114}, number = {1}, pages = {341--353}, publisher = {Am Physiological Soc}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Grimes, William N; Graves, Logan R; Summers, Mathew T; Rieke, Fred A simple retinal mechanism contributes to perceptual interactions between rod-and cone-mediated responses in primates Journal Article Elife, 4 , pp. e08033, 2015. @article{grimes2015simple,
title = {A simple retinal mechanism contributes to perceptual interactions between rod-and cone-mediated responses in primates}, author = { William N Grimes and Logan R Graves and Mathew T Summers and Fred Rieke}, url = {https://scholar.google.com/scholar?oi=bibs&cluster=4676850522193214001&btnI=1&hl=en}, year = {2015}, date = {2015-06-22}, journal = {Elife}, volume = {4}, pages = {e08033}, publisher = {eLife Sciences Publications Limited}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Sinha, Raunak; Hoon, Mrinalini; Okawa, Haruhisa; Wong, Rachel; Rieke, Fred Signal processing in the fovea: A specialized mode of synaptic integration by midget ganglion cells Journal Article Investigative Ophthalmology & Visual Science, 56 (7), pp. 5863–5863, 2015. @article{sinha2015signal,
title = {Signal processing in the fovea: A specialized mode of synaptic integration by midget ganglion cells}, author = { Raunak Sinha and Mrinalini Hoon and Haruhisa Okawa and Rachel Wong and Fred Rieke}, url = {https://scholar.google.com/scholar?hl=en&as_sdt=0,48&cluster=1631040095856979744}, year = {2015}, date = {2015-06-11}, journal = {Investigative Ophthalmology & Visual Science}, volume = {56}, number = {7}, pages = {5863--5863}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Brainard, David H; Jiang, Haomiao; Cottaris, Nicolas P; Rieke, Fred; Chichilnisky, EJ; Farrell, Joyce E; Wandell, Brian A Isetbio: Computational tools for modeling early human vision Inproceedings Imaging Systems and Applications, pp. IT4A–4, Optical Society of America 2015. @inproceedings{brainard2015isetbio,
title = {Isetbio: Computational tools for modeling early human vision}, author = { David H Brainard and Haomiao Jiang and Nicolas P Cottaris and Fred Rieke and EJ Chichilnisky and Joyce E Farrell and Brian A Wandell}, url = {https://www.osapublishing.org/abstract.cfm?uri=ISA-2015-IT4A.4}, year = {2015}, date = {2015-06-07}, booktitle = {Imaging Systems and Applications}, pages = {IT4A--4}, organization = {Optical Society of America}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
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Azevedo, Anthony W; Doan, Thuy; Moaven, Hormoz; Sokal, Iza; Baameur, Faiza; Vishnivetskiy, Sergey A; Homan, Kristoff T; Tesmer, John JG; Gurevich, Vsevolod V; Chen, Jeannie; others, C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor Journal Article Elife, 4 , pp. e05981, 2015. @article{azevedo2015c,
title = {C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor}, author = { Anthony W Azevedo and Thuy Doan and Hormoz Moaven and Iza Sokal and Faiza Baameur and Sergey A Vishnivetskiy and Kristoff T Homan and John JG Tesmer and Vsevolod V Gurevich and Jeannie Chen and others}, url = {https://scholar.google.com/scholar?oi=bibs&cluster=11382027315440429347&btnI=1&hl=en}, year = {2015}, date = {2015-04-24}, journal = {Elife}, volume = {4}, pages = {e05981}, publisher = {eLife Sciences Publications Limited}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Puller, Christian; Manookin, Michael B; Neitz, Jay; Rieke, Fred; Neitz, Maureen Broad thorny ganglion cells: A candidate for visual pursuit error signaling in the primate retina Journal Article Journal of Neuroscience, 35 (13), pp. 5397–5408, 2015. @article{puller2015broad,
title = {Broad thorny ganglion cells: A candidate for visual pursuit error signaling in the primate retina}, author = { Christian Puller and Michael B Manookin and Jay Neitz and Fred Rieke and Maureen Neitz}, url = {http://www.jneurosci.org/content/35/13/5397.short}, year = {2015}, date = {2015-04-01}, journal = {Journal of Neuroscience}, volume = {35}, number = {13}, pages = {5397--5408}, publisher = {Soc Neuroscience}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Hass, CA; Angueyra, JM; Lindbloom-Brown, Z; Rieke, F; Horwitz, GD Chromatic detection from cone Journal Article 2015. @article{hass2015chromaticb,
title = {Chromatic detection from cone}, author = { CA Hass and JM Angueyra and Z Lindbloom-Brown and F Rieke and GD Horwitz}, url = {https://rieke-server.physiol.washington.edu/Publications/pdfs/jov_Nov2015.pdf}, year = {2015}, date = {2015-01-01}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2014 |
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Ala-Laurila, Petri; Rieke, Fred Coincidence detection of single-photon responses in the inner retina at the sensitivity limit of vision Journal Article Current Biology, 24 (24), pp. 2888–2898, 2014. @article{ala2014coincidence,
title = {Coincidence detection of single-photon responses in the inner retina at the sensitivity limit of vision}, author = { Petri Ala-Laurila and Fred Rieke}, url = {http://www.sciencedirect.com/science/article/pii/S0960982214013372}, year = {2014}, date = {2014-12-15}, journal = {Current Biology}, volume = {24}, number = {24}, pages = {2888--2898}, publisher = {Elsevier}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Rudd, Michael E; Rieke, Fred Slow neural adaptation to photon noise explains square-root threshold and brightness laws in human rod vision Journal Article Journal of Vision, 14 (15), pp. 44–44, 2014. @article{rudd2014slow,
title = {Slow neural adaptation to photon noise explains square-root threshold and brightness laws in human rod vision}, author = { Michael E Rudd and Fred Rieke}, year = {2014}, date = {2014-12-02}, journal = {Journal of Vision}, volume = {14}, number = {15}, pages = {44--44}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Trenholm, Stuart; McLaughlin, Amanda J; Schwab, David J; Turner, Maxwell H; Smith, Robert G; Rieke, Fred; Awatramani, Gautam B Nonlinear dendritic integration of electrical and chemical synaptic inputs drives fine-scale correlations Journal Article Nature neuroscience, 17 (12), pp. 1759–1766, 2014. @article{trenholm2014nonlinear,
title = {Nonlinear dendritic integration of electrical and chemical synaptic inputs drives fine-scale correlations}, author = { Stuart Trenholm and Amanda J McLaughlin and David J Schwab and Maxwell H Turner and Robert G Smith and Fred Rieke and Gautam B Awatramani}, url = {http://www.nature.com/neuro/journal/v17/n12/full/nn.3851.html?foxtrotcallback=true}, year = {2014}, date = {2014-12-01}, journal = {Nature neuroscience}, volume = {17}, number = {12}, pages = {1759--1766}, publisher = {Nature Research}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Grimes, William N; Hoon, Mrinalini; Briggman, Kevin L; Wong, Rachel O; Rieke, Fred; others, Cross-synaptic synchrony and transmission of signal and noise across the mouse retina Journal Article retina, 3 (4), pp. 5, 2014. @article{grimes2014cross,
title = {Cross-synaptic synchrony and transmission of signal and noise across the mouse retina}, author = { William N Grimes and Mrinalini Hoon and Kevin L Briggman and Rachel O Wong and Fred Rieke and others}, url = {https://scholar.google.com/scholar?oi=bibs&cluster=16051891897689183687&btnI=1&hl=en}, year = {2014}, date = {2014-09-01}, journal = {retina}, volume = {3}, number = {4}, pages = {5}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Brinkman, Braden AW; Weber, Alison; Rieke, Fred; Shea-Brown, Eric Noise-and stimulus-dependence of the optimal encoding nonlinearities in a simple ON/OFF retinal circuit model Journal Article BMC Neuroscience, 15 (1), pp. P47, 2014. @article{brinkman2014noise,
title = {Noise-and stimulus-dependence of the optimal encoding nonlinearities in a simple ON/OFF retinal circuit model}, author = { Braden AW Brinkman and Alison Weber and Fred Rieke and Eric Shea-Brown}, url = {https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-15-S1-P47}, year = {2014}, date = {2014-07-21}, journal = {BMC Neuroscience}, volume = {15}, number = {1}, pages = {P47}, publisher = {BioMed Central}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Doan, Thuy; Dunn, Felice; Rieke, Fred Effects of sildenafil on primate retinas Journal Article Investigative Ophthalmology & Visual Science, 55 (13), pp. 1887–1887, 2014. @article{doan2014effects,
title = {Effects of sildenafil on primate retinas}, author = { Thuy Doan and Felice Dunn and Fred Rieke}, url = {http://iovs.arvojournals.org/article.aspx?articleid=2267171}, year = {2014}, date = {2014-04-30}, journal = {Investigative Ophthalmology & Visual Science}, volume = {55}, number = {13}, pages = {1887--1887}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Rudd, Michael Eugene; Rieke, Fred Brightness in human rod vision is regulated by neural adaptation to photon statistics Journal Article Investigative Ophthalmology & Visual Science, 55 (13), pp. 3001–3001, 2014. @article{rudd2014brightness,
title = {Brightness in human rod vision is regulated by neural adaptation to photon statistics}, author = { Michael Eugene Rudd and Fred Rieke}, url = {http://iovs.arvojournals.org/article.aspx?articleid=2268385}, year = {2014}, date = {2014-04-30}, journal = {Investigative Ophthalmology & Visual Science}, volume = {55}, number = {13}, pages = {3001--3001}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Manookin, Michael B; Puller, Christian; Rieke, Fred; Neitz, Maureen; Neitz, Jay A non-spiking, wide-field amacrine cell that rapidly integrates visual signals over long distances in the primate Journal Article Investigative Ophthalmology & Visual Science, 55 (13), pp. 2640–2640, 2014. @article{manookin2014non,
title = {A non-spiking, wide-field amacrine cell that rapidly integrates visual signals over long distances in the primate}, author = { Michael B Manookin and Christian Puller and Fred Rieke and Maureen Neitz and Jay Neitz}, url = {http://iovs.arvojournals.org/article.aspx?articleid=2268003}, year = {2014}, date = {2014-04-30}, journal = {Investigative Ophthalmology & Visual Science}, volume = {55}, number = {13}, pages = {2640--2640}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Grimes, William N; Schwartz, Gregory W; Rieke, Fred The synaptic and circuit mechanisms underlying a change in spatial encoding in the retina Journal Article Neuron, 82 (2), pp. 460–473, 2014. @article{grimes2014synaptic,
title = {The synaptic and circuit mechanisms underlying a change in spatial encoding in the retina}, author = { William N Grimes and Gregory W Schwartz and Fred Rieke}, url = {http://www.sciencedirect.com/science/article/pii/S0896627314001688}, year = {2014}, date = {2014-04-16}, journal = {Neuron}, volume = {82}, number = {2}, pages = {460--473}, publisher = {Elsevier}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Okawa, Haruhisa; Santina, Luca Della; Schwartz, Gregory W; Rieke, Fred; Wong, Rachel OL Interplay of cell-autonomous and nonautonomous mechanisms tailors synaptic connectivity of converging axons in vivo Journal Article Neuron, 82 (1), pp. 125–137, 2014. @article{okawa2014interplay,
title = {Interplay of cell-autonomous and nonautonomous mechanisms tailors synaptic connectivity of converging axons in vivo}, author = { Haruhisa Okawa and Luca Della Santina and Gregory W Schwartz and Fred Rieke and Rachel OL Wong}, url = {http://www.sciencedirect.com/science/article/pii/S0896627314001147}, year = {2014}, date = {2014-04-02}, journal = {Neuron}, volume = {82}, number = {1}, pages = {125--137}, publisher = {Elsevier}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Bleckert, Adam; Schwartz, Gregory W; Turner, Maxwell H; Rieke, Fred; Wong, Rachel OL Visual space is represented by nonmatching topographies of distinct mouse retinal ganglion cell types Journal Article Current Biology, 24 (3), pp. 310–315, 2014. @article{bleckert2014visual,
title = {Visual space is represented by nonmatching topographies of distinct mouse retinal ganglion cell types}, author = { Adam Bleckert and Gregory W Schwartz and Maxwell H Turner and Fred Rieke and Rachel OL Wong}, url = {http://www.sciencedirect.com/science/article/pii/S0960982213015790}, year = {2014}, date = {2014-02-03}, journal = {Current Biology}, volume = {24}, number = {3}, pages = {310--315}, publisher = {Elsevier}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Latimer, Kenneth W; Chichilnisky, EJ; Rieke, Fred; Pillow, Jonathan W Inferring synaptic conductances from spike trains with a biophysically inspired point process model Inproceedings Advances in Neural Information Processing Systems, pp. 954–962, 2014. @inproceedings{latimer2014inferring,
title = {Inferring synaptic conductances from spike trains with a biophysically inspired point process model}, author = { Kenneth W Latimer and EJ Chichilnisky and Fred Rieke and Jonathan W Pillow}, url = {http://papers.nips.cc/paper/5262-inferring-synaptic-conductances-from-spike-trains-with-a-biophysically-inspired-point-process-model}, year = {2014}, date = {2014-01-01}, booktitle = {Advances in Neural Information Processing Systems}, pages = {954--962}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
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Barreiro, Andrea K; Gjorgjieva, Julijana; Rieke, Fred; Shea-Brown, Eric When do microcircuits produce beyond-pairwise correlations? Journal Article Frontiers in computational neuroscience, 8 , 2014. @article{barreiro2014microcircuits,
title = {When do microcircuits produce beyond-pairwise correlations?}, author = { Andrea K Barreiro and Julijana Gjorgjieva and Fred Rieke and Eric Shea-Brown}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915758/}, year = {2014}, date = {2014-01-01}, journal = {Frontiers in computational neuroscience}, volume = {8}, publisher = {Frontiers Media SA}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2013 |
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Manookin, Michael; Puller, Christian; Rieke, Fred; Neitz, Jay; Neitz, Maureen ON parasol ganglion cells of the primate retina exhibit directional sensitivity Journal Article Investigative Ophthalmology & Visual Science, 54 (15), pp. 1296–1296, 2013. @article{manookin2013parasol,
title = {ON parasol ganglion cells of the primate retina exhibit directional sensitivity}, author = { Michael Manookin and Christian Puller and Fred Rieke and Jay Neitz and Maureen Neitz}, year = {2013}, date = {2013-01-01}, journal = {Investigative Ophthalmology & Visual Science}, volume = {54}, number = {15}, pages = {1296--1296}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Turner, Maxwell; Zylberberg, Joel; Cafaro, Jon; Shea-Brown, Eric; Rieke, Fred Spike correlations and direction encoding in the retina Journal Article Investigative Ophthalmology & Visual Science, 54 (15), pp. 3396–3396, 2013. @article{turner2013spike,
title = {Spike correlations and direction encoding in the retina}, author = { Maxwell Turner and Joel Zylberberg and Jon Cafaro and Eric Shea-Brown and Fred Rieke}, year = {2013}, date = {2013-01-01}, journal = {Investigative Ophthalmology & Visual Science}, volume = {54}, number = {15}, pages = {3396--3396}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Schwartz, Gregory W; Rieke, Fred Controlling gain one photon at a time Journal Article Elife, 2 , pp. e00467, 2013. @article{schwartz2013controlling,
title = {Controlling gain one photon at a time}, author = { Gregory W Schwartz and Fred Rieke}, year = {2013}, date = {2013-01-01}, journal = {Elife}, volume = {2}, pages = {e00467}, publisher = {eLife Sciences Publications Limited}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Cafaro, Jon; Rieke, Fred Regulation of spatial selectivity by crossover inhibition Journal Article Journal of Neuroscience, 33 (15), pp. 6310–6320, 2013. @article{cafaro2013regulation,
title = {Regulation of spatial selectivity by crossover inhibition}, author = { Jon Cafaro and Fred Rieke}, year = {2013}, date = {2013-01-01}, journal = {Journal of Neuroscience}, volume = {33}, number = {15}, pages = {6310--6320}, publisher = {Soc Neuroscience}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Angueyra, Juan M; Rieke, Fred Origin and effect of phototransduction noise in primate cone photoreceptors Journal Article Nature neuroscience, 16 (11), pp. 1692–1700, 2013. @article{angueyra2013origin,
title = {Origin and effect of phototransduction noise in primate cone photoreceptors}, author = { Juan M Angueyra and Fred Rieke}, year = {2013}, date = {2013-01-01}, journal = {Nature neuroscience}, volume = {16}, number = {11}, pages = {1692--1700}, publisher = {Nature Research}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Zylberberg, Joel; Turner, Maxwell; Hu, Yu; Cafaro, Jon; Schwartz, Greg; Rieke, Fred; Shea-Brown, Eric Consistency requirements determine optimal noise correlations in neural populations Journal Article BMC Neuroscience, 14 (1), pp. F1, 2013. @article{zylberberg2013consistency,
title = {Consistency requirements determine optimal noise correlations in neural populations}, author = { Joel Zylberberg and Maxwell Turner and Yu Hu and Jon Cafaro and Greg Schwartz and Fred Rieke and Eric Shea-Brown}, year = {2013}, date = {2013-01-01}, journal = {BMC Neuroscience}, volume = {14}, number = {1}, pages = {F1}, publisher = {BioMed Central}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Puller, Christian; Manookin, Michael; Neitz, Maureen; Rieke, Fred; Neitz, Jay Response properties of broad thorny ganglion cells in the primate retina Journal Article Investigative Ophthalmology & Visual Science, 54 (15), pp. 1295–1295, 2013. @article{puller2013response,
title = {Response properties of broad thorny ganglion cells in the primate retina}, author = { Christian Puller and Michael Manookin and Maureen Neitz and Fred Rieke and Jay Neitz}, year = {2013}, date = {2013-01-01}, journal = {Investigative Ophthalmology & Visual Science}, volume = {54}, number = {15}, pages = {1295--1295}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Grimes, William; Rieke, Fred Dynamic interactions between rod and cone signaling pathways in the inner retina Journal Article Investigative Ophthalmology & Visual Science, 54 (15), pp. 3391–3391, 2013. @article{grimes2013dynamic,
title = {Dynamic interactions between rod and cone signaling pathways in the inner retina}, author = { William Grimes and Fred Rieke}, year = {2013}, date = {2013-01-01}, journal = {Investigative Ophthalmology & Visual Science}, volume = {54}, number = {15}, pages = {3391--3391}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Angueyra, Juan; Rieke, Fred Asymmetries between ON and OFF responses in primate vision first arise in photoreceptors Journal Article Investigative Ophthalmology & Visual Science, 54 (15), pp. 1293–1293, 2013. @article{angueyra2013asymmetries,
title = {Asymmetries between ON and OFF responses in primate vision first arise in photoreceptors}, author = { Juan Angueyra and Fred Rieke}, year = {2013}, date = {2013-01-01}, journal = {Investigative Ophthalmology & Visual Science}, volume = {54}, number = {15}, pages = {1293--1293}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Okawa, Haruhisa; Santina, Luca Della; Schwartz, Greg; Kerschensteiner, Daniel; Rieke, Fred; Wong, Rachel Distinct Roles Of Activity-Dependent And Independent Mechanisms In Regulating The Bipolar Cell Inputs Onto Retinal Ganglion Cells Journal Article Investigative Ophthalmology & Visual Science, 54 (15), pp. 4562–4562, 2013. @article{okawa2013distinct,
title = {Distinct Roles Of Activity-Dependent And Independent Mechanisms In Regulating The Bipolar Cell Inputs Onto Retinal Ganglion Cells}, author = { Haruhisa Okawa and Luca Della Santina and Greg Schwartz and Daniel Kerschensteiner and Fred Rieke and Rachel Wong}, year = {2013}, date = {2013-01-01}, journal = {Investigative Ophthalmology & Visual Science}, volume = {54}, number = {15}, pages = {4562--4562}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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Schwartz, Greg; Grimes, William; Rieke, Fred An interaction between parallel circuits alters the state of a synapse and the retinal representation of visual space Journal Article Investigative Ophthalmology & Visual Science, 54 (15), pp. 1760–1760, 2013. @article{schwartz2013interaction,
title = {An interaction between parallel circuits alters the state of a synapse and the retinal representation of visual space}, author = { Greg Schwartz and William Grimes and Fred Rieke}, year = {2013}, date = {2013-01-01}, journal = {Investigative Ophthalmology & Visual Science}, volume = {54}, number = {15}, pages = {1760--1760}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2012 |
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Rudd, Michael E; Rieke, Fred Time course of square-root law adaptation in human rod vision Journal Article Journal of Vision, 12 (14), pp. 48–48, 2012. @article{rudd2012time,
title = {Time course of square-root law adaptation in human rod vision}, author = { Michael E Rudd and Fred Rieke}, year = {2012}, date = {2012-01-01}, journal = {Journal of Vision}, volume = {12}, number = {14}, pages = {48--48}, publisher = {The Association for Research in Vision and Ophthalmology}, keywords = {}, pubstate = {published}, tppubtype = {article} } |