Werner's Syndrome: Data Files

Chromosome 2: ApoB

• Data file for homozygosity mapping: homoApod.dat



• Linkage analysis with Genehunter:

  Data file: apob3gh.dat.

  Parameter files: apob_ca.par, apob_cj.par, apob_jp.par.

  Genehunter output: ghcau.out, ghjca.out, ghjap.out.

Chromosome 8

• Original Data files with 35 markers:

  The group columns in both data files tell the ethnic origin of the individuals where 0 = Japanese and 1 = non-Japanese. In the control group, all non-Japanese were Caucasians.

  • Cases: CASEall.dat
  • Controls: CONTall.dat
  
  
  
• Individuals with pedigree information

  Among the Japanese patients in the orginal data, 16 of them were from the families in the above pedigree data apob3gh.dat. Those people were selected for linkage analysis with above pedigree structures.

  • Those 16 individuals with all 35 markers: wsjapchr8.dat. ID is their id number in file apob3gh.dat.
  • Allele frequencies for alleles present in those individuals, calculated separately from Japanese and Caucasian controls. chr8freqs.dat.
  
  
  
• Informative markers

  A subset of the markers (13) was selected for linkage analysis since many of the markers are very close to each other and not informative for linkage analysis.

  • Pedigree data for linkage analysis with Genehunter: ws8ped.dat.
  • GH Parameter files: wschr8_Jap.par, wschr8_Cau.par.
  • GH output files: ghchr8jp.out, ghchr8ca.out.