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Current Roles:<\/strong><\/p>\n Sr. Research Scientist, Department of Pharmaceutics<\/a><\/p>\n ADMET and Modeling Leader, TLC-ART<\/a> Drug Development Program<\/p>\n Project Lead, QPS, and PBPK initiatives<\/p>\n Director of SAAM II<\/a> software & consulting<\/p>\n ORCID<\/a>: 0000-0003-4498-7823<\/a><\/p>\n <\/p>\n Simone Perazzolo, Ph.D., is a Modeling and Simulation Scientist who leads the TLC-ART program’s preclinical and clinical pharmacokinetics and modeling initiatives. His expertise includes mechanistic modeling of biological and pharmacological systems, with a focus on PBPK modeling for nanoparticles, long-acting drugs, and extended-release formulations. Simone has also developed the first whole-body PBPK lymphatic<\/a> system to study particle<\/a> and other large molecules (eg, vaccine) distribution in the lymphatic system. He is involved in model-informed drug development for anti-cancer drugs and SARS-CoV2 antivirals, as well as understanding parenteral routes of administration and viral clearance in special populations.<\/p>\n Dr. Perazzolo has more than 10 years of experience in modeling and simulation in life science. Previously, he worked at the University of Virginia (VA) in tuning the FDA-approved glucose-insulin regulation simulator in the so-called Artificial Pancreas Project<\/a> under the supervision of Profs C. Cobelli and B. Kovatchev. His Ph.D. is in biomedical engineering and mathematical modeling at the University of Southampton (UK) with a thesis titled \u201cModelling the Nutrient Transfer across the Placenta<\/em>\u201d under the supervision of Doctor Sengers and placentologist Doctor Lewis. In 2020, Dr. Perazzolo completed his 3-year postdoctoral fellowship at the UW School of Pharmacy under the supervision of Profs Danny Shen<\/a> and Rodney Ho<\/a>, with a track record of PK modeling publications about novel long-acting antiretroviral formulations for targeted long-acting HIV therapy, one of which was awarded the June 2020 front page in the Journal of Pharmaceutical Sciences<\/em><\/a>.<\/p>\n Simone is a two-time recipient of the Outstanding Early Career Scientist award from The Editorial Staff and the American Pharmacists Association for his work in modeling and pharmacokinetics, published in the Journal of Pharmaceutical Sciences<\/em>, class of 2022<\/a> and 2024<\/a>.<\/p>\n Social:<\/strong> Pubmed,<\/a> Researchgate<\/a>, LinkedIn<\/a><\/p>\nBio<\/h4>\n
Awards, Media and Conferences<\/h4>\n
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