{"id":2677,"date":"2023-03-05T15:19:36","date_gmt":"2023-03-05T23:19:36","guid":{"rendered":"https:\/\/depts.washington.edu\/tlcart\/?page_id=2677"},"modified":"2025-10-08T10:14:43","modified_gmt":"2025-10-08T17:14:43","slug":"pipeline","status":"publish","type":"page","link":"https:\/\/depts.washington.edu\/tlcart\/news\/about\/pipeline\/","title":{"rendered":"TLC-ART Pipeline"},"content":{"rendered":"<p>TLC stands for &#8220;Targeted Long-acting Combination&#8221; of drugs intended to simultaneously knock out multiple drug targets within the cells of viral infected cells or occult cancer cells.<\/p>\n<p>TLC products are designed to reach tissue and cell targets, taken up into the cells and persist intercellular to maximally suppress and eliminate occult cells in the body. The synchronized exposure in cells is enabled by Drug-combination Nano-Particle technology called <em><strong>DcNP<\/strong><\/em>. Injectable drug-combination product formulated in <em><strong>DcNP<\/strong><\/em> dosage form has demonstrated to provide long-acting intracellular and plasma pharmacokinetic characteristic.<\/p>\n<p>The following list contains drug combination product candidates and their research and development status toward clinical translation.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-3139\" src=\"https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/Graphic-1-300x118.png\" alt=\"\" width=\"595\" height=\"234\" srcset=\"https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/Graphic-1-300x118.png 300w, https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/Graphic-1-1024x403.png 1024w, https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/Graphic-1-1536x605.png 1536w, https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/Graphic-1-2048x806.png 2048w, https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/Graphic-1-375x148.png 375w, https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/Graphic-1-1200x473.png 1200w\" sizes=\"auto, (max-width: 595px) 100vw, 595px\" \/><\/p>\n<div class=\"accordion \" id=\"tlc-art-pipeline-in-details\">\n<div class=\"screen-reader-text\">TLC-ART Pipeline in details<\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">HIV<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\">\n<p> Latest publication on HIV <\/p>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">HBV<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\">\n<p> coming soon <\/p>\n<\/div>\n<\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">Cancer<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\">\n<p> coming soon <\/p>\n<\/div>\n<\/div>\n<\/div>\n<hr \/>\n<p>\t\t<a href=\" https:\/\/depts.washington.edu\/tlcart\/publications\/\" class=\"btn btn-sm arrow gold\"><span>Publications<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/a><\/p>\n<p><span style=\"color: #ff9900;\">Last Update: Oct 8, 2025<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>TLC stands for &#8220;Targeted Long-acting Combination&#8221; of drugs intended to simultaneously knock out multiple drug targets within the cells of viral infected cells or occult cancer cells. TLC products are designed to reach tissue and cell targets, taken up into the cells and persist intercellular to maximally suppress and eliminate occult cells in the body. The synchronized exposure in cells is enabled by Drug-combination Nano-Particle technology called DcNP. Injectable drug-combination product formulated in DcNP dosage form has demonstrated to provide&#8230;<\/p>\n<div><a class=\"more-link\" href=\"https:\/\/depts.washington.edu\/tlcart\/news\/about\/pipeline\/\">Continue reading <span class=\"screen-reader-text\">TLC-ART Pipeline<\/span><\/a><\/div>\n","protected":false},"author":4,"featured_media":0,"parent":8,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-small-hero.php","meta":{"footnotes":""},"class_list":["post-2677","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/pages\/2677","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/comments?post=2677"}],"version-history":[{"count":28,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/pages\/2677\/revisions"}],"predecessor-version":[{"id":3140,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/pages\/2677\/revisions\/3140"}],"up":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/pages\/8"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/media?parent=2677"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}