{"id":1073,"date":"2017-02-07T23:10:23","date_gmt":"2017-02-07T23:10:23","guid":{"rendered":"http:\/\/depts.washington.edu\/tlcart\/?p=1073"},"modified":"2018-10-29T22:58:59","modified_gmt":"2018-10-29T22:58:59","slug":"a-single-dose-of-tlc-art-lasting-over-2-weeks","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/tlcart\/a-single-dose-of-tlc-art-lasting-over-2-weeks\/","title":{"rendered":""},"content":{"rendered":"<figure id=\"attachment_1079\" aria-describedby=\"caption-attachment-1079\" style=\"width: 732px\" class=\"figure figure-caption wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1079\" src=\"https:\/\/depts.washington.edu\/tlcart\/wp-content\/uploads\/Aids-Publicaton-Group-Cropped.jpg\" width=\"732\" height=\"379\" \/><figcaption id=\"caption-attachment-1079\" class=\"wp-caption-text\">From Left to Right: Loren Kinman, Lisa McConnachie, Josefin Koehn and John C. Kraft <\/figcaption><\/figure>\n<p>In the AIDS journal, the TLC-ART team reported that a dose of HIV drug combination, targeted to the residual virus\u00a0in lymph nodes-exhibiting\u00a0drug insufficiency, persisted with high levels over 2 weeks. Currently HIV patients take multiple pills\u00a0daily and do not have drug levels high enough to clear the virus in the nodes. The results,\u00a0improved lymph node drug\u00a0levels over two weeks, was demonstrated in monkeys and will be published in the March 2017 issue of AIDS, one of the most respected HIV\/AIDS journals. John Kraft, Lisa McConnachie, Josefin Koehn, Loren Kinman, Carol Collins, Danny Shen, Ann Collier and Rodney Ho lead the research team. The linked article is entitled, \u201c<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Long-acting+combination+anti-HIV+drug+suspension+enhances+and+sustains+higher+drug+levels+in+lymph+node+cells+than+in+blood+cells+and+plasma\" target=\"_blank\" rel=\"noopener noreferrer\">Long-acting combination anti-HIV drug suspension enhances and sustains higher drug levels in lymph node cells than in blood cells and plasma<\/a>\u201d<\/p>\n<p>A pre-print version of this article is available <a href=\"http:\/\/journals.lww.com\/aidsonline\/Fulltext\/2014\/11130\/Long_acting_three_drug_combination_anti_HIV.17.aspx\" target=\"_blank\" rel=\"noopener noreferrer\">online<\/a><\/p>\n<p>This study is sponsored by NIH Grant\u00a0 UM1 AI120176.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the AIDS journal, the TLC-ART team reported that a dose of HIV drug combination, targeted to the residual virus\u00a0in lymph nodes-exhibiting\u00a0drug insufficiency, persisted with high levels over 2 weeks. Currently HIV patients take multiple pills\u00a0daily and do not have drug levels high enough to clear the virus in the nodes. The results,\u00a0improved lymph node drug\u00a0levels over two weeks, was demonstrated in monkeys and will be published in the March 2017 issue of AIDS, one of the most respected HIV\/AIDS&#8230;<\/p>\n<div><a class=\"more-link\" href=\"https:\/\/depts.washington.edu\/tlcart\/a-single-dose-of-tlc-art-lasting-over-2-weeks\/\">Continue reading <span class=\"screen-reader-text\"><\/span><\/a><\/div>\n","protected":false},"author":4,"featured_media":1085,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1073","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/posts\/1073","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/comments?post=1073"}],"version-history":[{"count":19,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/posts\/1073\/revisions"}],"predecessor-version":[{"id":2112,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/posts\/1073\/revisions\/2112"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/media\/1085"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/media?parent=1073"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/categories?post=1073"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/tlcart\/wp-json\/wp\/v2\/tags?post=1073"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}